conjunctivitis Flashcards

1
Q

what is conjunctivitis

A
  • inflammation of conjunctiva
  • most common cause of red eye worldwide
  • inflammation can be hyperacute, acute or chornic
  • caused by infection or toher factors like allergic, chemical, mechanical, dermatologial, systemic or lacrimal system infections
  • Acute (less than 3-4 weeks) vs chronic (>4 weeks)
  • usually self limiting
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2
Q

What are teh 3 types of conjunctivitis

A
  • viral, bacterial and allergic
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3
Q

previlance of viral conjunctivitis

A
  • peak prevalence in summer
  • adenovirus infections most common (65-90%) followed by herpes simplex
  • other viruses: varicella zoster, molluscum contagiousum
  • oftne misdiagnoses as bacterial conjunctivitis
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4
Q

previlance of bacterial conjunctivitis

A

2nd most common

  • 50 -75% cases in children in winter months
  • staphylococcal specis most common, followed by streptococcus pneumoniae and haemophilus influenza
  • neisseria gonorrhoeae or chlamydia trachomatic cause more serious hyperacute infection
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5
Q

previlance of allergic conjunctivitis

A

non-infectious, least frequent

  • peak in spring and summer
  • immediate hypersensitivity, allergy to seasonal pollens or allergic reactions to eye rpoducts
  • chemical or irritative cuases include dry eye, drug induced dry eye
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6
Q

clinical presentation of viral conjunctivites

A
  • Generalized redness, serous (watery) discharge, burning, foreign body sensation, itching, unilateral symptoms initially that may progress bilaterally
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7
Q

clinical presentation of bacterial conjunctivitis

A
  • Generalized redness, purulent (viscous, yellow/green colour) secretion with sticky eyelids in the morning, minimal itching
  • Hyperacute bacteria conjunctivitis symptoms include rapid onset, purulent discharge, diminished visual acuity, eye tenderness and swollen lymph nodes
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8
Q

clinical presentation of allergic conjunctivitis

A

Mild to severe ocular itching, redness and watery or mucoid discharge, mild eyelid swelling and bilateral presentation

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9
Q

what are the risk factors for conjunctivities

A

● Exposure to someone infected with active viral or bacterial conjunctivitis

● Contact lens use, poor contact lens hygiene

● Foreign body exposure

● Use of contaminated cosmetic eye products

● Chronic dry eye or blepharitis

● Use of ophthalmic or other medications that might cause allergic reactions or dry eyes

● Immunosuppression, rheumatological disease, allergic rhinitis

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10
Q

what information to collect for SCHOLAR

A
  • S: redness, discharge, itching
  • C: water, serous, purulent, mucopurulent, hyperpurulent discharge • History of contact lens use, exposure to person with red eye, URI
  • O:acute presentation 1-2 days vs chronic
  • L: conjunctiva vs eyelid or around the eye
  • A: risk factors for dry eyes, blunt trauma, chemical exposure
  • R: what has been tried before
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11
Q

HAMS for conjunctivitis

A
  • H: history of ocular disease, intermittent episodes of red eye, history of atopy, current URI, Sjogren’s, rheumatoid arthritis, thyroid disorder, rosacea
  • A: allergies to medications or environment
  • M: medications with anticholinergic side effects, beta blockers, hormone-based therapy, antineoplastics, allergy medications, nonprescription or natural medications, recreational drugs/opiate

s• S: history of smoking, alcohol use and caffeine use, hobbies, travel, sexual history, use of illicit drugs

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12
Q

Red flags signs and symptoms of conjunctivitis

A

● Contact lens wearer due to the high risk of corneal ulcer

● Visual loss, blurred vision, halos

● Moderate to severe pain or ocular trauma

● Severe or hyperpurulent discharge or any corneal involvement

● Photophobia or coloured halos around lights

● Irregular pupils- fixed, smaller, larger

● Visible corneal opacity or haze

● Rash +/-blisters around eye or redness at the corneoscleral junction, ciliary flush

● Foreign body sensation

● Severe headache with nausea, vomiting

● Bacterial ophthalmic infections in children

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13
Q

differential diagnosis

A
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14
Q

what are the goals of therapy

A
  • Eliminate or reduce signs and symptoms
  • Restore or maintain normal vision
  • Prevent complications (preserve eyesight)
  • Prevent recurrence
  • Cure or control infection where present and prevent transmission of infection to others
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15
Q

what are the non-pharmacological recommendations for conjunctivitis

A
  • Cold compresses for allergic or viral conjunctivitis
  • Warm compresses or soak for bacterial conjunctivitis
  • Sterile saline irrigation or refrigerated commercial eye wash
  • Eyelid wipes for blepharitis
  • Infection prevention and control measures
  • Contact lens wears should stop using contact lens and seek medical advice
  • Avoid environmental triggers for allergic conjunctivitis
  • Encourage proper use of eye drops and recommend discarding contaminated or older eye drop bottles
  • Discard old eye cosmetic/eye make up products being used
  • Review use of other medications that can worsen eye conditions
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16
Q

pharmacological treatment for Viral conjuncivitis

A
  • adenoviral conjunctivitis is self limiting
  • no proven treatment for eradication of virus
  • treatment for viral infection mainly supportive
  • > arificial tears or ocular lubricants (cold) ex: carboxymethylcellulose or polyvinyl alcohol
  • > Opthalmic decongestants or antihistamine/decongestant combinations (can help with severe itching)
    ex: maphazoline, oxymetazoline or antazoline/nephazoline

*decongestants/vasoconstrictors may provide angle closure glaucoma (reserved for occasional short term use)

17
Q

Drugs used for adjunctive or supportive drug therapties for virual conjunctivities

A

ocular lubricants

opthalmic vasoconstictior monotherapy

antihistamine/ophthalamis vasoconstictor

18
Q

describe does/directions, safety and considerations for

ocular lubricant

A

*treatment of viral conjunctivitis

Dose/directions: 1-2 drops TID to QID

safety: preservative toxicity, filmy/blurry vision
considerations: preferable to use preservative free product to minimize eye irritation

19
Q

describe does/directions, safety and considerations for

Ophthalmic vasoconstrictor monotherapy

A

ex: . Naphazoline, oxymetazoline, phenylephrine, tetrahydrozoline

dose/directions: 1-2 drops every 3 to 4 hours or up to QID ≤ 3-4 times per month and ≤ days in a row

safety: Minor stinging on instillation, pupillary dilatation and angle closure glaucoma in predisposed patients
considerations: Ophthalmic vasoconstrictors are meant for occasional and short-term use. Overuse may cause rebound hyperemia

20
Q

Antihistamine/ophthalmic vasoconstrictor/combinations

A

Eg. Antazoline/naphazoline Pheniramine/naphazoline

dose/directions: 1-2 drops every 3 to 4 hours or up to QID ≤ 3-4 times per month and ≤ days in a row

safety: Minor stinging on instillation, pupillary dilatation and angle closure glaucoma in predisposed patients
considerations: Ophthalmic vasoconstrictors are meant for occasional and short-term use. Overuse may cause rebound hyperemia

21
Q

describe pharmacological treatment for bacterial conjunctivitis

A
  • usually self-limiting and resolves within 7 to 10 days
  • Refer children to primary care provider or optometrist
  • No evidence of superiority of any topical antibiotic agent
  • Consider preference for ophthalmic drops vs ointment formulations
  • OTC treatment for mild infection (small amounts of discharge, tearing mild burning)

-> Polymyxin B/gramicidin combinations

• Rx treatment for moderate infection (copious amounts of discharge and tearing, moderate burning)

-> Erythromycin, trimethoprim/polymyxin B, tobramycin

22
Q

OTC treatment for bacterial conjunctivitis

A

polymyxin B gramicidin eye/ear drops

  • directions: 1-2 drops 4-6 times/day F5-7D
  • chronic use can cause corneal epithelium toxicity, allergy and bacterial resistance
  • use for mild infections, if no improvement after three days refer
23
Q

what are the prescription treatments for bacterial conjunctivitis

A
  • erthromycin 0.5% ointment

Fusidic acid 1% viscous eye drops

Trimethoprom/polymyxin 0.3% opthalmic drops

  • fluoroquinolones: besifloxacin 0.6%, cuprofloxacin 0.3%, gatifloxacin 0.3%, Moxifloxaci 0.5% ofloxacin 0.3%
24
Q

describe directions, safety and considerations of Erthromycin 0.5% ointment

A

sig: 1 xm 2-6x daily F1W

Antibacterials: chronic use can cause corneal epithelum toxicity, allergy and bacterial resistance

considerations: moderate to severe infection

25
Q

describe directions, safety and considerations of Fusidic acid 1% vascous eye drops

A

directions: 1 drop q12h x f7d
- Antibacterials: chronic use can cause corneal epithelium toxicity, allergy and bacterial resistance

moderate to severe infection

26
Q

describe directions, safety and considerations of Trimethoprim/polymyxin B 0.1%-10,000 units/mL

A
  • 1-2 drops 4-6 times daily for 1 week
  • antibacterials: chronic use can cause corneal epithelium toxicity, allergy and bacterial resistance
  • moderate to severe infection Age > 2 months
27
Q

describe directions, safety and considerations of Trobramycin 0.3% opthalmic drops

A
  • directions; 1-2 drops QID F5D
  • antibacterials: chronic use can cause corneal epithelium toxicity, allergy and bacterial resistance
  • moderate to severe infection
28
Q

when to use fluoroquinolones for bacterial conjunctivitis

A
  • reverse for serious infection
  • must be older than 1yo
29
Q

what is pharmacoligical treatment for allergic conjuctivitis

A
  • first line treatment is to identify and remove allergens
  • OTC treatment options; aftificial tears or saline solution, antihistamine/decongestant drops, mast cell stabilizers
  • Rx treatment options: Dual acting antihistamines with mast cell stabilizing properites if OTC products have failed (ketotifen, olopatadine)
30
Q
A
31
Q

how to implement treatment for conjunctivitis

A
  • patient counselling
  • > Provide instructions about medication dose, frequency, duration of treatment and how to appropriately use eye drops
  • > Recommend non-pharmacological treatment such as proper handwashing
  • > If patient is a child, counsel parents on appropriate time to return to school or daycare: Return to school 24 hours after starting treatment for bacterial injections, Viral conjunctivitis is contagious
  • > Recommend environmental controls/triggers for allergic conjunctivitis
32
Q

monitor and follow up for bacterial conjunctivitis

A
  • asses therapy for safety: follow up within 2-3 days to check for adverse drug event or intolerance within 7 days to assess if refer is required
  • Assess thearpy for efficacy: follow up in 2 days for bacterial, 3 for allergic, 1 week fo vira
  • determine if goald achieves: dec signs and symptoms, decreased discomfort, control over it, no complications,
  • further follow up required if worsening symptoms/no improvement: bacterial: 48h, allergic 3 days, viral 1 week