Congenital infections Flashcards
What is the most common infective cause of congenital hearing loss?
CMV
“blueberry muffin rash” + sensorineural deafness
Rubella
Rubella - what does negative IgM and IgG indicate
Patient is susceptible to rubella
Rubella- what does negative IgM and positive IgG indicate
Immune -Vaccinated or previous infection
Rubella - what does positive IgM and positive IgG indicate
Acute infection or false positive IgM
What is the incidence of congenital CMV infection?
0.2%-2.2% (1 in 50-1 in 500)
What proportion of babies with congenital CMV will develop symptoms at birth?
10-15%
What proportion of babies with congenital CMV will develop symptoms after 2 years?
10-15%
What is the risk of VZV causing congenital disease in first trimester
0.4%
What is the risk of VZV causing congenital disease in second trimester
2%
Incidence of listeria infection in pregnancy
12 per 100,000
What is the fetal mortality rate with listeriosis?
20-30%
Management of a genital Herpes lesions at 32 weeks gestation
Swab to confirm HSV
Bloods to determine whether this is a primary or initial infection or recurrence
Start acyclovir until birth
If a primary or initial infection advise C-section delivery
What is the difference between a primary or initial HSV infection?
Primary - first ever infection with either HSV 1 or HSV 2
Initial- has previously had either a HSV 1 or HSV 2 infection and has since developed another HSV infection i.e. previously HSV2 and now has HSV 1
What is the mortality rate with disseminated neonatal herpes?
30%
