Condition CF Flashcards
Abdominal aortic aneurism
Mostly men over 65. Most are aysymptomatic until rupture, but can cause mild to severe persistant central abdominal pain or persistant low back pain. A pulsing feeling may be felt when touching near the umbilicus. There may also be associated vascular claudication in the lower limbs - leg pain and weakness on exercising, quickly releived by rest.
Angina equivalent
More common in women. Dyspnoea with little or no chest pain. History of chest tightness and close correlation with exercise.
Aortic disection (thoracic)
Very rare. Risk if HBP, known thoracic aortic aneuysm, Marfan’s syndrome or Ehlers-Danlos syndrome. Sudden onset severe, sharp, tearing excruciating chest pain may begin near shoulder blades. Possible sweating , nausea and vomiting. Pain follows the path of dissection. CT,MRI or echocardiogram to investigate/confirm.
Arrhythmia
Irregular heart beat. Possible dyspnoea if there is a structural heart abnormality. Can cause collapse or stroke. Other symptoms: palpitations, dizziness, fainting. Possible oliguria and uraemia. Risk factors: Old age, excess alcohol, overweight. History of MI or heart failure. Congenital. Drug reaction.
Atherosclerosis
Older people with family history and lifestyle risks (smoking, obesity, alcohol, diet, personality, social deprivation, diabetes). Male or post menopausal women. Asymptomatic at first. Can cause angina, MI, embolism or CVE. May have history of high BP and cholesteral.
DVT
Calf pain and tenderness. Low grade fever. Pitting oedema around ankle. Patient may have risk factors: immobility, injury to vein or increased clotting.
Heart failure (dilated cardiomyopathy) - acute
Dyspnea - orthopnoea, extremely tired, agitated, pale, clammy, pulse rapid, cool peripheries. Left - more respiratory symptoms - rapid shallow respiration. Wheeze. Unable to speak. Can cause renal failure, hypo or hyperkalaemia, hyponatraemia, thromboembolism, arrhythmia, impaired liver function. Most common cause of premature death.
Heart failure (dilated cardiomyopathy) - chronic
Dyspnoea at first with moderate exertion, gradually provoked by less exertion. Orthopnaea - use of pillows, waking in night. Cheyne-stokes respiration. Relapsing and remitting. Fatigue, listlessness, cold peripheries. Swollen ankles. Weight loss. R - Hepatomegaly, ascties and peripheral oedema. L - Pitting oedema, pulmonary oedema & pleural effusion.
Hypertention
May be assymptomatic. Hypertensive retinopathy. Can lead to aortic aneurysm and dissection, hypertensive encephalopathy and stroke, heart failure, cardiomegaly, atrial fibrillation, hypertensive nephropathy and kidney failure. More common in black americans and japanese. Can be genetic factors. High salt intake, heavy alcohol consumption, obesity, lack of exercise, drugs. Can indicate renal dysfunction, insulin resistance, phaeocromocytoma, cushings syndrome, adrenal tumour or thyrotoxicosis.
Mitral valve prolapse
Risk factors: Older people. High blood pressure. History of rheumatic heart disease, endocarditis, congential heart defect, marfans syndrome. May be asymptomatic. Sharp left sided muscualoskeletal like pain that patient can point to. Shortness of breath, tiredness, dizziness. Can lead to arrhythmia, palpitations, pulmonary hypertension and heart failure.
Myocardial Infaction (MI) - Heart attack
Cardiac pain (dull heavy, squeezing, crushing burning) in centre of chest, neck, jaw, arms, possibly back, without exertion. Dyspnoea. Orthopnoea. Discomfort rather than pain. Takes several minutes or longer to develop. Sweating, nausea, vomiting. Collapse/syncope. Pallor. Nitroglycerin does not help. Onset can be sudden or gradual. Women more likely to get non pain symptoms. Most likley caused by blod clot due to atherosclerosis, but can be other reasons.
Peripheral artierial disease
In West - atheroscelosis is main cause. 20% have it but only 1 in 4 have symptoms. Associated with diabetes. Pain caused by intermittent vascular claudication in calves, buttock, hip or thigh, when walking or climbing stairs. Quickly releived with rest. Hair loss, numbness or weakness,muscle wasting, ulcers, blue shiny skin - all on legs. Brittle toenails. Erectile dysfunction.
Reynauds phenomenum/disease - primary
Mostly young women aged 25 to 30 in temperate climates, genetic link. White fingers triggered by cold, anxiety and stress lasting minutes to hours. Cyanosis and rubor. Not usually painful. Can also affect toes.
Reynauds phenomenum/disease - secondary
Older people with vibration injury or thoracic outlet obstruction (TOS), RA or lupus. White fingers triggered by cold, anxiety and stress lasting minutes to hours. Cyanosis and rubor. Can progress to ulceration, necrosis and pain. Can also affect toes.
Ruptured abdominal aortic aneurysm
Acute abdominal or lumbopelvic pain - onset in minutes. General malaise and leg weakness. Possible vascular claudication.
Stable angina
Effort related cardiac pain (dull heavy, squeezing, crushing burning in centre of chest, neck, jaw, arms, possibly back) similar to MI, but relieved by rest or nitroglycerin. Predicable. Long term. Dyspnoea. Also brought on by emotion, large meal or cold wind. Most likley caused by atherosclerosis in coronary artieries, but can be other reasons.
Temporal Arteritis
Headache at front and side of head possibly back or top of head with proximal muscle weakness or tenderness, jaw claudication and visual disturbances - diplopia. Possible history of polymyalgia rheumatica. New headache in older patient - onset may be sudden. Paracetamol does not help. Extreme tiredness, anorexia, weight loss, depression.
Thoracic aortic aneurism
Over 50s, risk increasing with age. Men > Women. May be aysymptomatic until rupture, but can cause chest pain, back pain, difficulty breathing, coughing, wheezing, hoursness and difficulty swallowing. Risk factors: Smoking, HBP, Family histoy, marfans, TB.
Unstable angina
Very similar to MI. Cardiac pain (dull heavy, squeezing, crushing burning) in centre of chest, neck, jaw, arms, possibly back, at rest. Unpredictable (new onset or rapidly worsening). Lying flat. Nocturnal symptoms. Dyspnoea. Discomfort rather than pain, takes several minutes or longer to develop. Most likley caused by atherosclerosis in coronary artieries, but can be other reasons.
Vascular claudication
Bilateral calf pain - cramping aching. Does not depend on spinal position. Agrivated by physical exertion. Pain relieved promptly by rest. Sensory loss in stocking distribution. Cool, dry, scaly skin. Poor nail and hair growth. Decreased or absent pulses. 40-60+ yrs.
Venous hypertension
Back or leg pain with varicous veins or history of DVT. Swelling in lower legs. Tiredness. Leathery, flaking or itching skin or ulcers on legs or feet. More likely in older obese inactive or pregnant women.
Referred viceral pain - Heart (Angina, MI)
Dull, deep and boring, diffuse pain in central upper thoracics or left arm. Hypersensitive to touch.
Pulmonary embolism
Chest pain or dyscomfort similar to MI. Sudden severe persistant dyspnoea. Patient looks anxious. Signs of DVT - ankle oedema, calf tenderness. Smaller embolysm can cause heamoptysis and pleural chest pain. Causes: DVT. Inactivity. Blood vessel damage due to chemotherapy and vasculitis. Blood that clots too easily - Cancer, chemotharapy, radiotherapy, heart failure, thrombophillia, Hughes syndrome. Risk factors: Age > 60. Familial. Obese. Pregnant. Smoker. Combined pill or HRT.
Infectious mononucleosis
Severely sore thoat. Swollen gland in neck. Fatigue. Teenagers and young adults.
Infective endocarditis
Most common in patients with congenital or valvular heart disease or history of heart surgery. May not be painful. Subacute: Persistent fever, unusually tired, night sweats, weight loss or new signs of heart dysfuction. headache and muscle ache like flu. Acute: Fever. Prominent & changing heart murmers. Petechiae (bleeding spots). Post operative: Fever after heart valve surgery. Any: Subconjunctive haemorrhage. Roths spots in eye. Petechial haemorrage on mucous membranes or rash. Poor dental health. Systemic emboli - eg nail fold infarct. digital clubbing, splinter haemorrhages. Blood in urine. Oslers nodes.
Oral candidiasis
Odynophagia. Oral ulcers. White patches on tongue and buccal mucosa. Dysphagia. More common in babies, debilitated patients. Corticosteroid or antibiotics. DM. Immunosuppressed. Cytotoxic therapy. AIDS.
Acute pyelonephritis
Pain in the side, lower back and genitals. Fever. Shivering. Chills. Weak and tired. Loss of appetite. Nausea. Vomiting. Diarrhoea. May also show symptoms of lower UTI. Slightly more common in women. Additional for children: irritability, poor feeding, not growing at expected rate, abdonimla pain, jaundice, blood in urine, bed wetting.
Chronic pyelonephritis
Many be asymptomatic at first or repeated attacks of pain in the side, lower back and genitals. Fever. Shivering. Chills. Weak and tired. Loss of appetite. Nausea. Vomiting. Diarrhoea. May also show symptoms of lower UTI. Can be caused by obstruction repeated acute attacks or vesico-ureteral reflux.
Pelvic inflamatory disease possibly related to STD (Chlamydia, gonorrhoea)
Acute abdominal pain and possible lumbopelvic pain, that increases after menstruation in sexually active female. Fever, chills, dyspareunia (pain during intercourse) and abnormal vaginal discharge.
Urinary tract infection (Lower UTI)
Can be asymptomatic. Sudden onset frequency of micturition. Urgency. Dysuria (scalding pain in urethra during micturition). Suprapubic pain during and after voiding. Constant dull pain in pubic region. Back pain. Strangury (intense desire to pass more urine after micturition). Cloudy, unpleaseant smelling urine. Microscopic or visible haematuria. General sense of unwellness. Can lead to septicaemia. Very common. Women > men. Less common in children. Risk factors: Incomplete emptying from obstruction - kidney stones, neurological problems, uterine prolapse, vesico-ureteric reflux. Catheter or stent. Post menopausal vaginitis, or urethritis. DM. Chemotherapy, HIV. Extra risk for women: sexually active, use of diaphram or spermicide. Extra risk for men: enlarged prostrate.
Urinary tract infection (Upper UTI)
Uncontrollable shivering. Nausea. Vomiting. Diarrhoea. Moderate to severe pain in side, back or groin that is worse when urinating. May also display symptoms of lower UTI. Can spread from lower to upper. Women> Men, Risk factors as lower UTI
Viral hepatits
Headache. Myalgia. Arthralgia. Nausea. Anorexia. Jaundice. Vomitting. Diarrhoea. Abdominal discomfort. Dark urine. Pale stools. Symptoms rarely last more that 3 - 6 weeks. Can lead to acute liver failure, aplastic anaemia or relapsing hepatitis. Been abroad without vaccination (A), sexual contact with carrier (B), IV drug use (C), glandualr fever (Epstein Barr), immunocompromised (Cytomegalovirus)
Parasitic infection
Recurrent diarrhoea after recent travel
Bornholm disease /epidemic myalgia/coxsackie viral infection)
Severe stabbing chest pain worse when deep breathing, coughing or sudden movements. Pain is intermittent lasting 15 to 30 mins at a time. May also have headache, sore throat and muscle pain. Mainly under 30s and in epidemics during summer and autumn.
Infective/Septic arthritis
Hot, red, swollen joint. History of open wound, chronic inflammation or immunosupression.
Osteomyelitis
Diffuse aching pain in cervical, thoracic, lumber spine or limb. Sudden high temperature and malaise. Swelling, redness, warmth, tender to touch. Lymph glands swollen. May be history of trauma, DM,RA or sickle cell.
Arachnoiditis
Low back and leg pain following myelographic or spinal anaesthetic procedures. Possible cauda equina symptoms.
Herpes Zoster (Shingles)
Unilateral NOT bilateral , sharp, burning, recurrent chest pain with skin vesicles after a few days and hypersensitivity in dermosomal pattern. Radiates around chest and improves with antivirals. Reccurs with stress.
Pneumonia
Pleuritic chest pain. Dyspnoea. Cough with sputum. Chills. Clamminess. Blueness. Headaches. Loss of appetite. Mood swings. Nausea. Vomiting. Joint pain. Fatigue. Muscle aches. Spread by droplet infection. Can affect healthy individuals, some more predisposed through risk factors: Smoking. URTI. Alcohol. Corticosteroids. Old age. Recent flu injection. Lung disease. HIV. Indoor air pollution. More likely to be viral in children.
Tuberculosis - primary
Flu like symptoms. Respiratory chest pain. Lung consolidation and collapse. Obstructive emphysema. Pleural effusion. Meningitis. Pericarditis. Erythema nodosum. Phlyctenular conjunctivitis. Dactylitis. Pulmonary: Chronic cough with haemoptysis. Pyrexia. Pneumonia. Weight loss. Pneumothorax. Can have extra pulmonary symptoms. More common in developing countries. Risk from Smoking. HIV. Malignancy. DM type 1. Chronic renal failure. Silicosis. Malnutricion from GI disease. Vit A, D deficient. Recent measles.
Tuberculosis - milary
Respiratory chest pain. Fever. Night sweats. Anorexia. Weight loss. Dry cough. Headache. Crackles. Bone marrow - Anaemia, leucopenia. Extra pulmonary: Seizures, confusion, SOL, cranial nerve palsy, chronic back pain, kyphosis, chord compression, abdominla mass, ascites, Psoas abcess, monoarthritis, haematuria,dysuria, infertility in women, epidydimitis, pericardial effusion. Risk factors: Cancer. HIV. Malnutrician. DM. Silicosis. End stage renal disease. Major surgery.
URTI - cold, pharyngitis, acute bronchitis
Rapid onset. Sneeezing, sore throught, watery nasal discharge, cough, possible hearing impairement due to blockage of eustachian tubes. May have severe sore throat, hoarse or lost voice, pain on speaking with unproductive painful cough. May have fever. May develop to respiratory chest pain, retrosternal discomfort in trachea,wheeze, tight chest, mucopurulent sputum, may be blood stained.
URTI - Influenza
Sudden fever, aching, headache, anorexia, nausea, vomiting, harsh unproductive cough. Most recover in 3-5 days, but post viral syndrome can last for weeks. Mostly occurs as epidemic.
URTI’s - Sinusitis
Persistant headache after a cold or URTI. Dull throbbing pain in the upper face, cheeks, eyes and forhead. Fever, bad breath, reduced sense of smell. Purulent nasal discharge. Toothache. Fever. Worse in the morning.
Labrithitis
Constant dizziness. Acute onset. Slowly improves. May have some associated hearing loss or tinnitus. Can be caused by stress, head injury, virus or bacteria. May have had a cold just before.
Pericarditis (or myocarditis)
History of MI, cancer, infection, rheumatic fever or blunt trauma to chest. Retrosternal, left of sternum or L or R shoulder sharp pain. Varies with movement and respiration - catches during inpiration, coughing or lying flat. Can point to where pain is. Low grade fever.
Reumatic heart disease - acute rheumatic fever.
pericarditis, sore throat, fitting, erythema marginatum, subcutaneous nodules, dyspnoea, syncope, fever, oedema, polyarthritis. Explosive , halting speech. Emotional lability may present first. Chorea at late stage.Children between 5 and 15. Rare in western europe. Endemic in africa, asia and south america. History of recent strep infection or scarlet fever. Risk factors: malnutrition, poverty.
Gastritis
Dyspepsia - more discomfort than pain, Anorexia, Nausia, Vomiting, Haematemesis and Melaena. H Pylori is most common cause.
Appendicitis
Acute abdominal pain. Sudden onset. Young person. Poorly localised becoming more specific to RLQ within 2-12 hours. Nausea and vomiting. Annorexia, diahrroea.
Coeliac disease
Genetic suseptability. More common in northern europe. 1% prevalence in UK. Can present at any age, most common 30-50. Females > males. Linked to hyposplenism. 50% asymptomatic. Oral ulcers. Infants present with diarrhoea, malabsorbtion, failure to thrive. Older childen - delayed growth, puberty delay, mild abdominal distension, short stature in adulthood. Adults: Tiredness, weight loss, folate deficiency, iron deficiency anaemia, dyspepsia, bloating, undernutrition. Risk of osteoporosis.
IBD - crohn’s disease
Colicky pain in right lower abdomen, releived by defacation. Diarrhoea. Variable symptoms anywhere in GIT. Oral ulcers. Growth retardation. Sacroiliitis. Fistulous communication with bowel, skin, urinary bladder. General symptoms for IBD: Nausea. Vomiting. Weight loss. Relapse and remittance over years. Conjunctivitis, Iritis, Episcleritis. Mesenteric or portal vein thrombosis. Venous thrombosis. Arthralgia of large joints. Erythema nodosum. Pyoderma gangrenosum. Autoimmune hepititis. gall stones. Metabolic bone disease. Amyloidosis and oxylate caculi. Risk factors: Smokers. Ashkenazi jews. SLE. IBD patients with HLA B27 gene comonly develop AS.
IBD - ulcerative colitis
Mild lower abdominal cramps. Dehydration. Bloody diarrhoea. Tenesmus. Dehydration. Anorexia. Palor. Cholangitis and Cholangiocarcinoma. Toxic megacolon. General symptoms for IBD: Nausea. Vomiting. Weight loss. Relapse and remittance over years. Conjunctivitis, Iritis, Episcleritis. Mouth ulcers. Fatty liver. Liver abscess. Mesenteric or portal vein thrombosis. Venous thrombosis. Arthralgia of large joints. Erythema nodosum. Pyoderma gangrenosum. Autoimmune hepititis. gall stones. Metabolic bone disease. Amyloidosis and oxylate caculi. Risk factors: Genetic . Non smokers with appendix. IBD patients with HLA B27 gene comonly develop AS.
Irritable bowel syndrome
Colicky abdominal pain associated with defacation. Abdominal distention.Alternating constipation and diarrhoea. Rectal mucus. Feeling of incomplete defacation. Young women > men. Most common cause of GIT referral. Cause of absence from work and impaired quality of life. Stress worsens symptoms.
Ruptured appendix/ Peritonitis
Difuse acute abdominal pain in RLQ suddenly relieved, followed by increase in pain. Rigid abdomen. > Young person. Nausea and vomiting. Shortness of breath.
Pleurisy
Sharp chest and shoulder pain when breathing deeply, coughing, sneezing or moving. Shortness of breath and dry cough. Hisory of infection. Can point to pain.
Polymyalgia rheumatica
Pain and fever with weight loss and depression. Associated with temporal artieritis. Stiffness in the morning for > 45 mins. Extreme tiredness. Loss of appetite. Mostly over 70 when diagnosed. Rare in under 50s. More common in women. Normally starts with shoulders.
RA
Episodic pain, swelling and stiffness in joints, especially hands, feet and wrists. Throbbing aching pain, worse in morning for > 1 hour. Joints red and tender to touch. Bilateral. Multiple joints. May also have tiredness, fever, sweating, anorexia, weight loss. can affect eyes, heart and lungs. Can cause joint deformities. Commonly starts age 40 to 50. More women than men. Genetic tendancy.
Sacroiliac syndrome
SI joint pain. Radiation to hip, buttock, upper posterior thigh. Stabbing pain on lifting or straightening from stooped. Relieved by sitting or lying.
Frozen shoulder/Adhesive capsulitis
Frozen shoulder. Causes unknown but associated with trauma, immobilisation, diabetes (poor blood flow), thyroid issues and cardiac problems. More common in women. Usually non dominant side. Severe pain during freezing phase. Tender to touch. May disturb sleep. Agf: ext rotation. Lying on it. Alf: Arm in sling position. Pain lessens during frozen phase.
Leukemia
Tiredness, breathlessness, frequent infections, bleeding gums, nosebleeds in over 60 or children mostly 2 to 5 yrs. Tiredness, weight loss, night sweats, bloating, repeated infections, bruising and bone pain in 40 to 60 yrs.
Hodgkin’s lymphoma (HL) or Non-hodgkin lymphoma (NHL)
Swelling of neck armpit or groin. Night sweats. Unexplained weight loss. Persistent tiredness or fatigue. Recurrent infections and longer recovery. Persistant cough or feeling of breathlessness. Persitent itching all over body.
Multiple myeloma
Age 50+ Persistant LBP. Worse at night. Osteoporosis. Hypercalcaemia. Anaemia. Renal disease. Infection due to suppressed immune system.
Pituitary tumour (Benign adenoma)
Migraine like headache or cluster headache. Depression, anxiety or other mood changes. Can cause acromegaly, cushings.
Thyroid tumour
Pain in the neck and sometimes ears. Trouble swallowing. Trouble breathing. Hoarseness, Frequent cough not related to a cold.
Carcinoid bowel tumour/carcinoid syndrome
Mostly asymptomatic. Pain like appendicitis if obstruction. Pain in liver (from metastases). Flushing. Wheezing. Diarrhoea. Facial telangiectasia. Jaundice and hepatomegaly (from liver metastases). Carcinoid syndrome symptoms can include cardiac involvementfrom peptide hormones. Most common in appendix (benign) or rectum (malignant).
Colorectal cancer
Colicky lower adbominal pain. Rectal bleeding. Peritonitis. Localised abcess. Fistula formation. Aneamia. Weight loss. Palpable mass. Hepatomegaly from metastases. Left colon: Early bleeding and obtruction. Right colon: Amemia, altered bowel habit. Obstruction late. Rectum: Early bleeding, mucus discharge, feeling of incomplete emptying. Common in the west, > 50s, genetic predisposition and dietary factors - red meat and saturated fat, some(5%) have single gene mutation as the cause, IBD with PSC, uterosigmoidostomy, acromegaly, pelvic radiotherapy. Obesity. Smoking. Cholesistectomy. Type 2 diabetes. Reduced risk: Asprin, NSAIDS, statins.Fibre, fruit and veg, calcium, folic acid and omega 3.
Gastric carcinoma
50% have ulcer like pain. May be asymptomatic. Dyspepsia. Weight loss. Anorexia, Nausea. Early satiety. Haematemesis. Malaena. Disphagia if Gastro-oesophageal junction is obstructed. Anaemia. Palpable epigastric mass. Jaundice. Ascites. Dermatomyositis. Leading cause of cancer death worldwide. More common in China, Japan, South America. Environmental factors indicated. Men> women. > 50 yrs. Risk factors: salted, pickled, smoked food. Nitrites & Nitrates. Lack of Fresh fruit, veg, vit A, vit C. Genetic, blood group A, CDH1 gene auto somal dominant. History of gastritis (pernicious anaemia). Adenatemous gastric polyps in patient or family. Smoking. Alchohol. Previous partial gastrectomy.
Oesophageal tumour
Oesophageal chest pain. Progressive painless dysphagia. Bolus obstruction. Extreme weight loss in late stages. Cachexia. Hoarseness. Fistulation to trachea causing coughing, pneumonia, pleural effusion. Lymphadenopathy. metatastic spread.Squamous call carcinoma common in asia & africa. Risk factors - smoking, alchohol excess, betel nuts, tobacco, coeliac disease, achalasia, post cricoid web, post caustic stricture, tylosis. Adenocarcinoma increasing in West due to prevalence of GORD and Barrets oesophagus.
Oral cancer
Trismus (Pain opening mouth). Solitary Ulcer. White or red patch. Fixed lump. Lip numbness without trauma or infection. Cervical lymphadenopathy.Common worlwide. Incidence in UK increased by 25% over last decade. Risk factors: Poor diet, smoking, tobacco chewing, acohol excess, HPV virus. Chewing betel nuts (asia). Older adults. Men> women.
Benign prostatic hyperplasia (BPH)
Primary symptoms: Hesitancy. Poor prolonged flow. Sensation of incomplete emptying. Secondary symptoms: Frequency. Urgency. Urge incontinence. Emergency symptoms: Acute urinary retention. Anuria, painful distended bladder. Chronic symptoms: Chronc urinary reterntion. Pain free bladder dystention that can lead to hydroureter, hydronephrosis and renal failure or acute urinary retention. Men only. From age 40 prostate increases in size. Symptoms are common in > 60. 50% of > 80 have lower UT symptoms.
Prostate cancer
Symptoms same as BPH. (Hesitancy. Frequency. Urgency. Urinary retention. Anuria. Painful distended bladder. Mets cause lumbar and pelvic pain, weight loss, anaemia, obstruction of the ureters. Common in Northern Europe and USA, rare in China and Japan. > black population. 2nd most common malignancy in men. Rare < 50 yrs. Ave 70 yrs.
Renal adenocarcinoma
May be asymptomatic at first. Heamaturia. Loin pain, mass. Some have only one of these, some all three. Disorders of coagulation (too much) due to hormones from tumour. Rarely may present with neuropathy. Most common malignant tumour of the kidneys in adults. Males > females. 65 - 75 yrs. Unlikely < 40.
Testicular tumour
Painless testicular lump. Possible testicular ache. Possible gyneacomastia. Uncommon.Men. Age 20-40.
Urothelial tumour (Bladder, ureteral, urethral or Kidney tumour)
Painless, visible haematuria. Can also cause obstruction or dysuria. Males > Femles. Unlikely under 40. Mostly in urinary bladder and mostly benign
Hepatic tumour - Hepatocellular carcinoma (HCC)
May be asymptomatic at first. Features of cirrhosis if present. If no cirrhosis - Abdominal pain and weight loss. Possible hepatic rupture with abdominla bleeding. Most common primary liver tumour. 6th most common cause of cancer worldwide. More in asia, southern europe than northern europe. Risk factors: > In men. > with age. Cirrhosis major factor. Hep B infection. 4x risk if HBeAg present.
Pancreatic cancer (carcinoma)
Asymptomatic at first. Upper abdominal pain radiating to the lower back. Asymptomatic at first. Jaundice, loss of appetite, Cachexia, Depression, Vomiting from duodenal obstruction, Lymphadenopathy, scratch marks (Obstructive jaundice), venous thrombosis. Affects 1 in 1000 over 70s. Men> women 2:1. Risk factors: age, smoking, acute pancreatitis. DM. Obesity. Diet rich in red meat and lacking fruit and veg. 5 to 10 % patients have genetic predisposition.
Primary bone tumour
Gradual onset diffuse aching pain. Fatigue, weight loss fever, anaemia and unexplained fractures. More likely in young people or osteochondroma in hips, shoulders or pelvis.