CONDENSED - Cytokines, Chemokines and Receptors - Bailey Flashcards
Which Cytokines are considered adaptive?
IL-2, IL-4, IL-5 & IL-13
Which Cytokines are considered Innate?
TNF-alpha IL-1 IL-6 IL-12 (Induces INF gamma) INF gamma
What is the primary function of cytokines?
Mediating the immune system
What is the main difference between TH1 and TH2 based immunity?
TH1 = works in conjunction with CD8+ cytotoxic t cells and macrophages. - uses INF-gamma that activates macrophages to combat intracellular microbes.
TH2 = works in the in conduction with B cell antibodies, eosinophils and mast cells. - signature cytokines are IL-4,5 & 13 which activates mast cells and eosinophils.
*Both TH1 & TH2 use IL-2.
How do Chemokines contribute to Cell migration?
Through a Chemokine gradient to peripheral tissues.
_____ is the principal mediator of the acute inflammatory response to Gram - bacteria and stimulates recruitment of monocyte, neutrophils and t cells to site of infection.
TNF-Alpha
_______ has alpha and beta type that are the function which is the same function TNF-alpha.
IL-1
_____ has same function as TNF-alpha and IL-1.
IL-6
______ induces the production of INF-gamma.
IL-10
T or false, IL-12 activates macrophages directly.
False JORDAN!
_____ is responsible for growth, survival and differentiation of all t cells.
IL-2
______ primary function is to facilitate the ability of macrophages to kill intracellular microbes.
IFN-gamma
_____ is very similar to IL-4 (structurally and functionally)
IL-13
What do both IL-13 and IL-4 do?
Primary job is to help induce Ig isotope switch to IgE
_____ inhibits IL-12.
IL-10 (Inhibitory)
*Important because IL-12 does everything.
