Adaptive Immune Response to Extra-cellular Pathogens - Steiner/Jones

Question 1

Immune response to Extracellular pathogens is initiated by ___ & ____.

Answer 1

Macrophages & Neutrophils

Question 2

_____ Drives the Antibody response.

Answer 2

Th2 immunity

Question 3

_____ is considered the driver of Cell mediated immunity.

Answer 3

Th1 immunity

Question 4

The Humoral Immune response involves ________.

Answer 4

Antibody production

Question 5

True or false, Naive B cells produce antibodies.

Answer 5

False! B cells must become activated first before they can produce antibodies.

Question 6

B cells can be activated by ________ & _______.

Answer 6

Microbes & Soluble antigens

Question 7

After and Exposure to a Microbial infection, in what quantities relative to time would you expect to see Antibodies IgG and IgM?

Answer 7

Lots of IgM peaking at 3-5 days and then nearly double that number of IgG’s peaking at 10-14 days lasting much longer.
*IgG is usually T cell dependent
IgM is usually T cell independent

Question 8

B cell exposure to microbes can result in ________.

Answer 8

Changes in phenotype and function.

• Increased survival
• Proliferation
• Increased expression of b7 1 &2
• Increased expression of cytokine receptors
• increased expression of CCR7 and migration from follicle to T cell areas.

Question 9

B cell proliferation and differentiation occurs via a process called ______.

Answer 9

Colonal Expansion

Question 10

T cells and B cell interact in the ______.

Answer 10

Lymph nodes

Question 11

Isotype/Class Switching is Dependent on _______ and ______.

Answer 11

T cell interactions & Cytokines