Autoimmune Disease - Powell

Question 1

_______ recognize processed antigen in the context of MHC to irradicate infection.

Answer 1

T cells (cell mediated responses)

Question 2

_______ Recognize free antigen via lg receptor to irradicate infection

Answer 2

B cells ( Humoral responses)

Question 3

What is Autoimmune disease?

Answer 3

Group of 80+ chance illnesses that can involve almost every organ system.
- occurs when immune system beckons deregulated and attacks the very organ it was designed to protect.

Question 4

What are the Genetic factors surrounding Autoimmune disease?

Answer 4

• tend to occur in families and this concordance is largely genetic.
• Greater concordance between identical twins fro some diseases
• Strong HLA/MHC association

Question 5

Many AIM diseases affect _____ more than ______.

Answer 5

Women more than men

Question 6

What initiates an autoimmune response? (3)

Answer 6

• Incomplete deletion of self reactive cells
• Aberrant stimulation of “normally” anergic self reactive cells.
• Altered regulation of anergic self reactive cells.

Question 7

What are the 2 categories of autoimmune diseases?

Answer 7

Systemic = Immune cells target multiple organ systems and tissues.
Organ specific = targets specific organs or tissues.

Question 8

What are 2 common systemic AIM diseases?

Answer 8

Systemic Lupus Erythematosus (SLE)
Rheumatoid Arthritis (RA)

Question 9

What are 2 common Organ specific AIM diseases?

Answer 9

Insulin dependent diabetes
Multiple Sclerosis (MS)

Question 10

What are the symptoms and complications of SLE?

Answer 10

• Fatigue
• Fever
• Alopecia
• Mucosal ulceration
• Butterfly rash
• joint and muscle pain
• Complication include kidney, heart and lung complications.

*10x more common in females. onset age is 15-25

Question 11

What are the treatments for SLE?

Answer 11

Non steroidal anti inflammatory drugs are used to treat arthritic symptoms of lupus.

Corticosteroid creams for rashes.

Antimalarial drugs sometimes used for skin and arthritis symptoms.

*kidney transplant for advanced lupus.

Question 12

What are the symptoms and clinical features of Multiple sclerosis?

Answer 12

• impaired vision
• ataxia
• spasticity
• bladder dysfunction
• weakness/paralysis of limbs
• sensitivity to temp
• cognitive impairment
• Most common inflammatory disorder of the CNS
• More common in females 3:2
• Pathological hallmark is CNS plaque with loss of myelin and depletion of oligodendrocytes with or without bacon loss.
• Onset is childbearing years for women.

Question 13

What are the treatments for Multiple sclerosis?

Answer 13

• Immunomodulatory drugs
• Corticosteroids
• Immunosuppressive therapy