Conception and Fetal Development Flashcards

1
Q

Fertilization occurs when and where?

A

It occurs when there is a union of the nuclei of the sperm and ovum.
Location is in the outer third or ampulla of the fallopian tubes.

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2
Q

How long is the ovum fertile for?

How long can sperm survive? Fertile time phrame?

A

24 hours

Sperm can survive for 48-72 hrs.
Sperm are only fertile tho for 24 hrs as well.

(Sperm information contradicts her previous notes from family planning????)

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3
Q

So when the egg is released from the ovary & taken up into the fallopian tube - how does it move, again?

A

Ciliary movement and current pushes it along

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4
Q

How does the sperm move in order to meet the ovum?

A

Sperm have a tail that helps them move.

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5
Q

How many sperm should penetrate an ovum?

Which is bigger - ovum or sperm?

A

One sperm per ovum typically

The ovum is much bigger.

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6
Q

How is it that only one sperm can enter the ovum?

A

Zonal reaction or ability of the membrane to block other sperm.

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7
Q

What is conception?

What do the chromosomes do?

A

Formation of the zygote

The chromosomes then pair up. XX or XY

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8
Q

What does the zygote form into officially? And where does this formation burrow?

What is this process called? How many days should this take?

A

The zygote will form into the blastocyst.
And then the blastocyst will burrow into the endometrium - which is the inner lining of the uterus.

Process is known as implantation. Takes between 6-10 days.

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9
Q

What is the best site for implantation?

What name change occurs of the endometrium after implantation?

A

The side or posterior wall. NOT the front.

The endometrium or inner lining will have its name changed to decidua.

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10
Q

What is the site of implantation of the decidua (new name for endometrium)? What is it?

A

Decidua capsularis

It is a bubble structure that covers the blastocyst

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11
Q

What is is the maternal side of the placenta?

A

Decidua basalis. It serves as the base for the placenta.

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12
Q

What is the Decidua vera?

A

Remaining uterine lining of the decidua/endometrium that really isn’t all that affected by pregnancy.

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13
Q

Why are twins becoming more common?

A

Due to delayed child bearing and artificial reproductive treatments

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14
Q

Two types of twins?

A

Dizygotic

Monozygotic

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15
Q

Dizygotic twins
How many ovum and sperm needed?

How many placentas, chorians, amnions?

A

Two of everything because they are totally separate.

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16
Q

Will dizygotic twins always be the same gender?

A

No, these twins can be separate genders bc they’re separate in general.

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17
Q

What increases chances of having Dizygotic twins?

A

These twins are pretty much separate fyi…

Older pregnancy
Familial genes - twins tend to run in families
Going off the pill & having multiple ovum released.
Obesity

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18
Q

Monozygotic twins
Will have how many ovum and sperm?

How many placentas?

Will these be identical twins? Gender?

A

Will have one single fertilized ovum (so one sperm).

One shared placenta.

Yes - they are identical. Same gender as well.

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19
Q

Risk of monozygotic or identical twins?

What type of treatment could increase this?

A

Can become conjoined or have Siamese twinning where they are fused.

ART or artificial

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20
Q

Which types of twins will do better?

A

The Dizygotic twins will do better since they have their own stuff.
Monozygotic babies share placenta and possibly their chorion. Baby A gets the nutrients and Baby B is second.

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21
Q

Will blood ever be shared/mixed between mom and baby?

A

No - two separate circulatory systems going on. Unless there’s trauma and a vessel ruptures.

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22
Q

What do babies do to amniotic fluid that surrounds them?

A

They recycle it by drinking and peeing in it.

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23
Q

Cotyledons of placenta

A

Beefy red sub-sections of placenta

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24
Q

Fetal side of placenta

A

Where cord comes off of and attaches to the fetus.

Shiny, gray color

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25
Q

How big is the placenta at 20 weeks

How big is it by term

A

Covers 1/2 of uterine surface

By term it is 6-9 inch diameter and about 1 Ib

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26
Q

What if a mom is Rh-?

A

There could be mixing of blood due to maternal antibodies if baby is positive (it’s a blood type)

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27
Q

While there shouldn’t really be any mixing of blood unless there is something rare or abnormal - can the mother’s circulation affect the baby in any way?

A

Yes. Maternal circulation can increase or decrease uterine blood flow. Same thing can happen with mother’s blood pressure.
Ex: hypertension can decrease the CO and thus uterus &. placenta aren’t perfused doesn’t get enough

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28
Q

Uterine souffle

A

Listening over to maternal blood vessels which is the pulse of the mother. Whoosh noise.

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29
Q

Funic souffle

A

To listen to HR over umbilical cord that equals FHR - but you don’t want to necessarily listen to this.
Do it over the baby’s back.

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30
Q

What does the placenta transport?

How does the placenta act as the lungs?

A

Nutrients
Waste
Antibodies the last month of pregnancy/mother’s gift/passive immunity

Takes care of gas exchange components like O2 and CO2

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31
Q

Major hormones from placenta

A

hCG - basis of pregnancy testing; found in blood & urine
hPL - metabolism & growth in pregnancy
Estrogen - growth hormone of breast, uterus, blood
Progesterone - keeps uterus quiet and calm

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32
Q

Dirty duncan presentation

A

When placenta presents maternal side up with the Cotyledons

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33
Q

Where should the cord be on the placenta

A

In the center - unless there is an abnormality

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34
Q

Umbilical cord contains how many arteries and veins

acronym?

A

2 arteriers
1 vein

AVA - arteries on side and vein in center

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35
Q

Umbilical artery

Umbilical vein

A

Takes deoxygenated blood to placenta

Takes oxygenated blood to to the fetus

so reverse of your circulation

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36
Q

Percent of umbilical cords that only have 1 artery and 1 vein?

A

1%

The baby will still be healthy - but want to take a closer look to make sure there aren’t any other issues.

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37
Q

Does it hurt the baby when you cut the cord?

A

No - there’s no pain receptors.

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38
Q

How long is the cord?

Why does the length matter?

A

Same length of baby so 20-22 inches

If the cord is too short then it can get too tight and seperate

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39
Q

Protein around the umbilical cord?

What does the high blood volume help with?

A

Wharton’s Jelly - gelatin substance and water. Cushions the vessels.
Will fall off after delivery

It can keep the cord from tangling up around baby neck or having a nuchal cord. Can kill the baby

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40
Q

Ultrasound and doppler blood flow study helps with what?

A

Complications of pregnancy. Can check for blood flow through the vessels

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41
Q

Amniotic sac or Bag of water layers (2)

Are they fused together?

A

Amnion or inner layer that develops from the blastocyst. It is thin,

Chorion or outer membrane of the sac. Develops from the trophoblast and is thick.

No, they are not fused together.

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42
Q

Amniotic fluid amount at 39 weeks?

Amount at 41 weeks?

Main point?

A

700-900 mL

500 mL

So - this is why we never want a pregnancy to go past 40 weeks bc the amniotic fluid decreases.

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43
Q

Polyhydraminos

A

Excessive amount of amniotic fluid greater than 2L

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44
Q

Why would a baby have too much amniotic fluid (polyhydraminos)?

A

Gi issue like esophageal problem where baby can’t swallow their own amniotic fluid and so the fluid never gets recycled. It just accumulates in the sac.

Other reason is there could be more than one fetus and so more fluid is needed.

Diabetes - glucose can transfer to baby and the baby enlarges but also pees out everything so the fluid accumultes

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45
Q

Oligohydramnios

A

Not enough amniotic fluid so like less than 300 mL
Fluid will be super concentrated

half of the normal amount too

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46
Q

Why would a baby have Oligohydraminos or not enough fluid in their amniotic sac?

A

Since the fluid is recycled -
baby may not be excreting fluids due to kidney issues
Maternal drug use can cause no kidney in child
Or Reduced blood volume so less fluid

Or post date PG so 41 weeks

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47
Q

Amniotic fluid ph ?

A

Alkaline or high ph

48
Q

What will amniotic fluid look like

A

full of cellular debris so cloudy but may come out clear

49
Q

What if amniotic fluid is red?

What if fluid is green?

A

Means there could be bleeding

Green could be stool or meconium

50
Q

Three sources of amniotic fluid?

A

Amnion cells
fetal urine
fetal lungs

51
Q

How to diagnose amount of amniotic fluid?

A

Fundal height . After 20 weeks - the weeks represent height.
So 21 weeks = 21 cms.

Sonogram by measuring AFI - amniotic fluid index or measurement of parts of placenta (5-18 is normal .. 26 is high)

subjective data - does the mother think her pregnancy is weird? Especially compared to other pregnancies?

52
Q

Amniosythesis

A

Analyze amniotic fluid by drawing out fluid from sac.

Can determine gender, chromosomal info.. etc. Maturity.

53
Q

How does amniotic fluid help with pressure?

A

It surrounds the fetus equally and keeps the pressure equal to develop normally

54
Q

How does amniotic fluid help with movement?

A

It creates a gravity free environment for the baby to move and float around - which also helps muscles.

55
Q

What does amniotic fluid help prevent?

A

Prevents fetus from sticking to the amnion sac.

56
Q

How does amniotic fluid control temp?

A

Well the baby will feel your temp so regulates constant body temp.
If you’re cold - your baby will be cold. If hot - they will be too.

57
Q

Do babies swallow amniotic fluid?

A

Yes - it their source of oral fluid.

And they excrete their urine. It is sterile tho.

58
Q

Why do the placenta and amniotic fluid have to manage fluids and electrolytes?

A

A fetus doesn’t have adequate kidneys and so the placenta and amniotic fluid take care of it.

59
Q

How does amniotic fluid affect lungs

A

Baby has to have amniotic fluid bc it helps with practice breathing in utero. Without it, baby can die when it’s birthed. Chest wall movement practice

60
Q

The amniotic fluid pushes against the cord.

If there isn’t enough - symptoms of oligohydramnios occur. What is this evidenced by?

A

Variable decelerations in HR

61
Q

How does amniotic fluid act as an intact bag?

A

Dilating wedge against the cervix in labor

However, often they’ll rupture the membrane of placenta to allow baby’s head to be the dilating wedge since its much harder.

62
Q

Order of fetal progression

A

zygote> blastocyst > embryo> fetus

63
Q

Embryo weeks

What develops in this time frame?

A

2-8 weeks

Organs

64
Q

After 9 weeks ?

A

Fetus

65
Q

Fetal development week 4 of the heart

A

Heart is beating at 28 days & circulating blood

66
Q

What does a week 5 embryo look like in shape?

A

a C shape

67
Q

Fetus at week 9?

A

Every organ system and external structure is present

68
Q

Fetus at week 12

What does the HR do as pregnancy ensues?

A

Resembles a human
Fetal heart tones can be heard , 120-160 usually

The HR will slow

69
Q

Fetus at week 16 development

A

The sonogram can now try to pick up whether a fetus is a boy or girl

70
Q

Fetus at week 20

A

Activity such as quickening is felt by the mom

Vernix (cheesy coating)
Lanugo (peach fuzz like growths on body)

FHR is heard by a fetoscope

71
Q

Fetus at week 24

A

Skin is now COVERED by vernix
Alveolar ducts and sacs are present with no surfactant
Lethicin begins showing up by 27 weeks! (can survive outside of uterus)

72
Q

Fetus at week 28

A

Lungs can now do mature gas exchange

Eyelids open

73
Q

Fetus at 36-40 weeks
weight
Lanugo and Vernix?

Genitals?

immunnity?

A

More weight gain due to subcutaneous fat

Lanugo and vernix begin to disappear

Testes descend to scrotum
Labia majora becomes more full to cover up other parts of vagina due to fat deposits from weight gain

Mother’s anitbody gift transfer complete

74
Q

Teratogen

A

Agent that can cause an abnormality in fetus structure

drugs
virus
radiation

75
Q

First system to function in embryo?

A

Circulatory system

76
Q

What determines a baby’s blood type

A

Parent genes

77
Q

How is that babies carry more O2 than adults

A

due to larger fHGB - which protects against hypoxia

78
Q

Will a baby or mother have more fHGB?

A

Baby

79
Q

If a baby’s FHR is higher than a humans, does that increase or decrease CO?

A

Will increase CO!

80
Q

Will an adult or baby have a higher pulmonary bp?

A

Baby bc of pulmonary vessel constriction & thus blood is diverted from lungs all together?

81
Q

How is that blood is able to flow back to the placenta in a fetus?

A

Fetal systemic pressure is just lower

82
Q

Ductus venosus

A

Shunt that helps bypass the liver in fetus since it is underdeveloped

83
Q

Ductus arteriosis

A

A different shunt which is between the Pulmonary and artery in order to drive blood from lungs to systemic circulation

84
Q

Foramen ovale

ASD?

A

Shunts blood from right atrium to left atrium via a small hole in heart
Eventually this will be covered again by a flap but if not, then you have an atrial septal defect

85
Q

At 24 weeks can the aveoli produce surfactant?

A

no. But the alveioli are present

86
Q

Then when can surfactant be produced?

important surfactant ratio?

A

28-32 weeks to ease breathing so alveoli dont stick together

Lecithin : Spinogomyelin
2:1 means mature lungs for breathing and this finally occurs around 35 weeks

87
Q

Conditions that accelerate lung development

A
Fetal stress
Maternal hypertension
Infections
Steriods (might be giving these for pre-term labors 24-34 weeks)
Placental dysfunction
88
Q

Conditions that delay lung development

A

Maternal diabetes
Maternal renal problems

These issues can cause a baby to be bigger than what the maternal week development shows. So, size does not determine maturity whatsoever.

89
Q

How can Oligohydramnios inhibit lung development?

A

It can cause there to be less fluid for the baby to able to practice breathing and so lungs don’t develop as well.

90
Q

Why would a C-section baby have more fluid in lungs upon birth?

A

A vaginal birth squeezes the fluid out of the baby as to facilitate its first breathe.

A c-section baby doesn’t experience that squeezing and so the fluid remains. Will have resp. distress until fluid is suctioned out or absorbed maybe 24 hrs.

91
Q

How do babies develop first ?

A

Proximal -distal

Head to toe

92
Q

How does oligohydramnios affect the musculture?

A

Inhibits normal development
contractures
deformities

93
Q

If you feel the baby move is this good or bad?

A

Good. Once you start to feel the quickening, you’ll want to feel this almost every day thereafter

94
Q

How often do babies sleep in the womb?

A

Every 20 min. It is a sleep wake cycle

95
Q

Will the vernix caseosa or cheesy coating increase or decrease as fetus gets closer to term? What about lanugo?

A

Decrease for both of them.

So if the baby is cheesy upon birth, that means it was an earlier labor than 40 weeks. Same with lanugo.

96
Q

Will fingernails or toenails develop first?

A

Fingernails first
Toenails second

Cephalocaudal development

97
Q

Can babies suck and swallow in PG?

When will a baby develop a gag reflex?

A

Yes!

8 months for protection

98
Q

Meconium

What if there is a passage that occurs in utero? Why can this be bad?

A

Tarry black green stool in NB. Will transition to yellow brown & stay yellow.

Could indicate maturity or means they’re hypoxic. If they become hypoxic to the point of apoxic - they can have anal sphincter relaxation which causes the utero poop.

Need to consider if maturity or stress.

99
Q

What is a meconium breech presentation?

A

meconium stained liquid on butt.

Should be head down for labor.

100
Q

How soon should a baby have meconium passage after birth?

What if they don’t?

A

48 hrs

Could indicate an imperforated anus that is not patent.
Will need surgery

or could be from meconium illeus due to cystic fibrosis due to it being in the family

101
Q

What week if urine formation started?

A

12 weeks - but it’ll be a small, clear amount, no smell

102
Q

How can a fetus have acid base balance issues very quickly?

A

Kidneys aren’t doing the excretion in this case.

103
Q

How soon should a baby urinate after birth?

A

Within 24 hrs

104
Q

Main function of the liver during PG?

A

Glycogen stores

Iron stores - if you’re anemic, after 5-6 months infant can develop anemia since theirs will be depleted

105
Q

Can a baby break down bilirubin ?

A

Not very well due to immature liver. They may develop jaundice - and we assess during first week of life.

106
Q

What does a baby’s sterile gut contribute to?

A

Cannot produce vit k and so all newborns receive an IM injection within 2 hrs of delivery
Vit k = keeps them from bleeding

107
Q

How should a mom control fetal metabolism?

A

Avoid hot environments that may make her hot or over heat ; hyperthermia
If not controlled can lead to dna synthesis issues.

108
Q

Brown fat

A

Fat the baby is born with

We metabolize it to produce heat

109
Q

White fat

A

Layer of insulation between skin and blood vessels - laid down last month of pregnancy. Keeps them warm and adds pink color to skin.

110
Q

How can some babies develop congenital hypothydroism? Is this more common than hyper?

A

They don’t produce thyroxine.

Can be either but hypo more often.

But babies need to be screened for thyroid function.

111
Q

When is the pancreas able to produce insulin?

What does Macrosomnia mean?

A

20 weeks

Big bodied baby

Glucose can cross the placenta and now the baby can store it - and they end up huge. Latter part of pregnancy . common in hyperglycemic moms

112
Q

What is passive immunity?

A

Gift to baby from mother in IGG

Keeps baby healthy for about 6 months

113
Q

Largest group of antibodies that crosses the placenta?

A

IGG

the gift antibody

114
Q

Antibodies from breatfreeding?

What systems does it help?

A

IGA

GI, GU and respiratory system from infection

115
Q

What antibodies are produced by the fetus?

A

IGM

will test this if they suspect sepsis