Concept of Loading and Maintenence Dose

Question 1

Steady state

Answer 1

Rate of administartion = Rate of elimination

Question 2

Importance of SS

Answer 2

Used to assess patient response to a drug and used to compute new dosing regimens

Question 3

Linear pk

Answer 3

when dose are increased, the steady state increases proportionally

Question 4

Non- linear pk

Answer 4

when doses are increased and the steady stae concentrations increase disproportionately

Question 5

if SS increase more than expected after dsosage increase

Answer 5

• the processes removing the drug from the body have become saturated
• meaning that they arent functioning properly and thus metabolism, in this sense elimination is affected

Question 6

if SS increases less than expected after a dose increase

Answer 6

• saturation of protein binding site - VA and disopyramide (meaning these drugs are unbound and free and are able to siffuse into tissues and after they get eliminated quickly-
• carbamazepine which is an autoinducer and it is responsible for its own metabolism

Question 7

Loading dose

Answer 7

initial dose given in large doses to quickly obtain an effective blood level.

Question 8

Maintenance dose

Answer 8

given after the inital dose, small quantity of drug that is required to maintain blood levels