Comprehension - L01-L02 Flashcards
What are the 4 principles of Cell Theory?
- All organisms are composed of one or more cells
- The cell is the structural unit of life
- Cells can only arise by division from a pre -existing cell
- Cells contain genetic information passed from parent to daughter cell
What are some key features of Eukaryotic cells that are NOT in Prokaryotes?
Nucleus and Cytoplasm
Membrane bound organelles
Cytoskeletal system
RER
Golgi
Mitochondrion
Chromosomes
What is a covalent bond?
A chemical bond in which electron pairs are shared between two atoms
What are polar molecules and are they hydrophobic or hydrophilic?
Molecules with an uneven distribution of charge because the component atoms have different electronegativites
(Hydrophilic)
What are non-polar molecules and are they hydrophobic or hydrophilic?
Covalent bonds have a nearly symmetrical distribution of charge because the component atoms have approx the same electronegativities. (Hydrophobic)
What are the 6 polar uncharged amino acids?
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Serine
Threonine
Glutamine
Asperagine
Tyrosine
Cysteine
What are the 5 Polar Charged Amino Acids?
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Aspartic Acid
Glutamic Acid
Lysine
Arginine
Histidine
What are the 8 Non Polar Amino Acids?
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Alanine
Valine
Leucine
Isoleucine
Methionine
Phenylalanine
Tryptophan
Proline
What is the single amino acid that can fit in either hydrophobic or hydrophilic environments?
Glycine
What is a non-covalent bond?
A relatively weak chemical bond based on attractive forces between oppositely charged regions
What is an ionic bond?
Electrostatic interaction that occurs between groups of opposite charges
What is a hydrogen bond?
Electrostatic interaction between hydrogen atom (which is covalently bound to a more electronegative atom) and a second electronegative atom
What are Van Der Waals interactions?
A weak attractive force due to transient asymmetries of charge within adjacent atoms or molecules
What is the hydrophobic effect?
The tendency of non polar molecules to aggregate in order to minimize their collective interaction with surrounding polar water molecules.
The cell membrane contains a bilayer of what?
Polar phosphates
Nonpolar fatty acid tails
What are the characteristics of saturated fatty acids?
They lack double bonds
What are the characteristics of unsaturated fatty acids?
One or more double bonds
Introduce a bend in the fatty acid
Natural occurring fatty acids have cis double bonds (bend)
Are phosphoglycerides also phospholipids?
Yes
All sphingolipids are phospholipids, T or F?
False. Only some sphingolipids are phospholipids
What are the characteristics of phosphoglycerides?
Built on a glycerol backbone
Glycerol + 2 fatty acid chains + Phosphate group + Additional group
In Phosphoglycerides, what are the charges of the following additional groups:
H (PA)
Choline (PC)
Serine (PS)
Ethanolamine (PE)
Inositol (PI)
H (PA): negative
Choline (PC): neutral
Serine (PS): negative
Ethanolamine (PE): neutral
Inositol (PI): negative
What 3 things are considered membrane lipids?
Phosphoglycerides
Sphingolipids
Cholesterol
What are sphingolipids built on?
Sphingosine
What is an example of a sphingolipid?
Ceramide: sphingosine + Fatty acid
What are the characteristics of a sphingolipid?
Amphipathic
Additional groups can be linked to head group
Longer and more highly saturated FAC than phosphoglycerides
What is the role of a sphingolipid?
Signal transduction, membrane structure, and sensing
If a carbohydrate is added to a sphingolipid, what is it called?
A glycolipid
What is a cerebroside?
A simple sugar (like galactose) is added to a sphingolipid to form a glycolipid
What is a ganglioside?
A cluster of sugars added to a sphingolipid to form a glycolipid
What are the characteristics of cholesterol?
Amphipathic
Makes up 20-30% of the plasma membrane lipids in some animal cells
Impair movement of the FAT of the phospholipids
What are the 4 general components of a phosphoglyceride?
Additional group
Phosphate
glycerol
2 FAT
Phospholipid is a broad category that is composed of some (____) and all (___)
Phospholipid is a broad category that is composed of some sphingolipids and all phosphoglycerides
What does membrane asymmetry affect?
Membrane permeability
Surface charge
membrane shape
stability
What do membrane carbohydrates do?
Play important roles as receptors, sorting membrane proteins, and in cell recognition
What are the 7 membrane functions?
- Compartmentalization
- Scaffold for biochem activities
- Selectively permeable barrier
- Solute transport
- Response to external stimuli
- Cell-cell communication
- Energy transduction