Compounding Drugs Flashcards
What characteristic of the steroid affects the efficacy and frequency of tx application.
Potency
Potency of steroids from most to least potent.
Clobetasol ->
Fluocinonide ->
TAC ->
Hydrocortisone
Factors to increase effectiveness of a drug.
1) Contact time of drug on the surface
2) Adhesion of the drug carrier to the tissue
3) Protection of the ulcer by the drug carrier
Factors that interfere with contact time of the drug.
- Wet mucosal surface
- Salivation
- Movement of the tongue
T/F:
The more adhesive a drug is, the more resistance it has to wash out from salivation and tongue movement.
True
How does the drug carrier protect the ulcer?
By creating a barrier from foreign particles and irritants.
This is a topical dosage form used to treat vesiuloulcerative conditions:
1) Hydrophilic polymer hydrates when contacted by water, which confers adhesion to the mucosa by forming a sticky gel matrix.
2) Gel provides a protective barrier that’s resistant to frictional forces of the tongue and mouth, protecting from pain and irritation.
3) Prolonged drug to skin contact (3-4 hrs).
4) Applied 3-4 times a day.
5) Administered via accordion puffer to lesion site.
6) Can be flavored to increased patient compliance.
Mucoadhesive Powder Bandage (Polyox 301)
This anesthetic is given 10 minutes prior to a procedure, lasts 90 minutes, and are lollipops or troches to reduce gag reflexes.
0.5% Tetracaine
This is applied 30 seconds -2 mins prior to root planing and scaling, and leads to statistically significant reduction in pain compared to a placebo.
Lido/Prilocaine
It’s best for a topical anesthetic to have this in order to provide a wider spectrum of anesthetic action
Multiple agents.
T/F:
Topical tx of orofacial pain is effective for both peripheral nerve sensitization and pain resulting from centralized nerve damage.
True
This drug increases salivary and sweat gland production for people with dry mouth.
Pilocarpine
