Compounding

Question 1

USP general chapter <795>

Answer 1

Provides standards, procedures, and definitions relating to nonsterile compounding of pharmaceutical products.

Question 2

Compounding

Answer 2

process of combining two or more commercially available products into a single preparation that is not commercially available.

Question 3

Nonsterile products include:

Answer 3

solutions, suspensions, ointments, lotions, creams, powders, suppositories, tablets, or capsules prepared for external or oral use.

Question 4

Trituration

Answer 4

using a mortar and pestle to grind a solid drug to reduce particle size or mix two solids together.

Question 5

Levigation

Answer 5

dispersing a drug solid into a small amount of mineral oil, glycerin, or other liquid before incorporating into a compounding base, like a cream.

Question 6

Geometric dilution

Answer 6

method of mixing a small amount of potent drug into an equal amount of inactive/nonpotent compound until all compound is mixed with the drug.

Question 7

Beyond Use Date (BUD)

Answer 7

assigned to all compounded preparations based on chemical and physical stability, compatibility, microbial growth, and other factors. Should not exceed the soonest expiration date of the ingredients. USP Chapter <795> provides guidelines for BUD assignment.

Question 8

UPS general chapter <797>

Answer 8

provides standards, procedures, and definitions for sterile compounding.

Question 9

What agencies develop guidelines and regulations related to sterile compounding, hazardous drug handling, and use of PPE to ensure workplace saftey?

Answer 9

OSHA and NIOSH