COMPOUDING LAB MIDTERM Flashcards
How to operate a class A torsion balance
- Arrest torsion
- Screw both knobs (left or right) same directions until they are equal- check the right side of balance
- To “0” balance
- Small knob -> arrest to release turn left
- View the displace
- Adjust it by using bottom knobs (inwards to the left, outward to the right)
- Look to arrest position
Prescription Label
- Name of patient
- Prescription number
- Date written or dispensed
- Directions for use
- Name of prescriber
- Pharmacy info
- Special cautionary statements
Prescription Requirements
Prescriber information Patient information Date prescribed/written Medication prescribed and dosage (denoted as: Rx: drug name and dosage) Medication information (quantity, dosage form, etc.) Patient directions Refills Prescriber signature
BUD
Determined from the date when preparation is compounded
Manufacturer expiration date cannot be used as only source to determine bud
BUD general stability and drug specific considerations:
Nature of drug and degradation
Dosage form and components
Potential microbial growth
Final container
Storage conditions
Duration of therapy
OBRA-90 Info
- Name and description
- Dosage form, route, and duration
- Adverse effects
- Precautions
- Refill info
- Storage
- Missed doses
Oleaginous internal phase with aqueous external phase
Oil in water (o/w)
Compound White Ointment
White petrolatum and white wax over heat
Solutions
Liquid preparations that contain one or more chemical substances dissolved in a suitable solvent or mixture of mutually miscible solvents
Syrup
Aqueous solutions containing sugar
Solubility
Indicates the maximum concentration to which a solution may be prepared with that agent and that solvent
FDA recommendation for OTC alcoholic products
- Children under 6yrs 0.5%
- Children 6-12yrs 5%
- Over 12yrs 10%
Diluted alcohol
Prepared by mixing equal volumes of water and alcohol (strength approximately 49%)
Dry Mixtures for Solution
- Insufficient stability to meet extended shelf-life
- Once reconstituted, solution remains stable for 7-14 days
Flavored Vehicles
Non-medicated syrups containing flavoring agents
Syrup Components
- Sugar
- Antimicrobial preservatives
- Flavorants
- Colorants
Trituration
Process of grinding a drug in a mortar to reduce its particle size
Levigation
Used in ointments to reduce the particle size and grittiness of added powders
Transdermal
Designed to deliver drugs through the skin into circulation for system effects
Ointments
Semisolid preparations intended for external application to the skin or mucous membranes
Hydrocarbon Ointment Bases
- AKA oleaginous bases
- Protect against the escape of moisture
- Difficult to wash off with water
- Ex. Petrolatum, white ointment, etc
Water-Removable Absorption Bases
- Oil in water emulsions resembling creams
- Easily washed from skin
- Have the ability to absorb serous discharges
- Ex. hydrophilic ointment
Water-Soluble Absorption Bases
- Do not contain oleaginous components
- Completely water washable
- Referred to as greaseless
- Used mostly for incorporation of solid substances
Base Selection Factors
Factors
- Desired release rate
- Desirability for topical or percutaneous absorption
- Desirability of occlusion of moister from skin
- Stability in ointment base
- Effect of drug on consistency etc
- Desire for a base that is easily water-washable
Ointment Incorporation
- Solids or liquids
- Components are mixed until a uniform preparation is attained by using a mortar/pestle, or a spatula and ointment slab