BSI EXAM 4 Flashcards
Which hormone is secreted from bone?
- Parathyroid
- Calcitonin
- Vitamin D
- Ostercalin
- 1,2,3
- All
4
What is the major organic component of the matrix?
- Hydroxyapaptide
- Magnesium hydroxide
- Collagen
- 1,2
- All
3
What is the major inorganic component of matrix?
- Hydroxyapaptide
- Magnesium hydroxide
- Collagen
- 1,2
- All
4
How do osteoblasts arise?
- Division of osteoclasts
- Fusion of monocytes
- Differentiation of osteogenic cells
3
How do osteocytes arise?
- Mutation of osteoclasts
- Fusion of monocytes
- Differentiation of osteogenic cells
- Maturation of osteoblasts
4
What is the function of osteoclasts?
- Bone formation
- Bone resorption
2
How do osteoclasts arise?
- Mutation of osteoblasts
- Fusion of monocytes
- From division and differentiation of osteocytes
- Differentiation of osteogenic cells
3
Compact bone and spongy bone are both organized into osteons
T or F
False
Bone muticellular unit (BMU) consists of:
- osteocytes
- osteoblasts
- osteoclasts
- 1 and 2
- 2 and 3
- all
5
What do osteoclasts secret to resorb bone?
- collagen
- alkaine phosphotase
- lysosomal enzymes
- acids
- 3 and 4 only
- all
5
where does collagen come from?
- secrete from osteocytes
- secreted from osteoblasts
- secreted from osteoclasts
- synthesized by collagenases with in the bone matrix
2
what is the function of alkaine phostase?
1, to initial calcification of mineral salt units
- plays role in the secretion of collagen
- to activate osteoclasts
- 1 and 2
- all
1
what effect does PTH have on RANKL and OPG expression?
- increase both
- decrease both
- increase RANKL and decrease OPG
- decrease RANKL and incerase OPG
3
What effect does estrogen have on RANKL and OPG expresion?
- increase both
- decrease both
- increase RANKL and decrease OPG
- decrease RANKL and incerase OPG
4
what effect does glucocorticortal have on RANKL and OPG expression?
- increase both
- decrease both
- increase RANKL and decrease OPG
- decrease RANKL and incerase OPG
3
Calcium is only biologically active when:
- ionized
- bound to albumin
- bound to anions
- 2 of the above
- all
1
what effect does PTH have on the kidney?
- increase reabsortion of both Ca and P
- decrease reabsorption of both Ca and P
- decrease rebsorption of Ca and increase reabsorption of P
- increase reabsorption of Ca and decrease reabsorption of P
4
what is the effect of calcitonin on the kidney?
- increase reabsortion of both Ca and P
- decrease reabsorption of both Ca and P
- decrease rebsorption of Ca and increase reabsorption of P
- increase reabsorption of Ca and decrease reabsorption of P
2
if the PTh gene was deleted, what would happento the calcium level?
- it would cause hypocalcimia
- it would cause hypercalcimia
1
which is the biologically active form of vitamin D?
- vitamin D2
- vitamin D3
- 25- hydroxyvitamin D3
- 1,25 hydroxyvitamin D3
- all
4
which enzyme is regulated by PTH?
- vitamin D 25 hydroxylase
- 1 and hydroxylase
- both
- hydroxylase where? kidney
osteoclasts do not express receptor accept PTH but they are still bone reabsorption. How PTH still stimulate in reabsorption?
RANKL osteblast expresses PTH
increase RANKL and decrease OPG stimulate RANK receptor
Glucocrticoid induced osteporosis is
- primary osteoporosis
- secondary osteoporosis
2
why would enzyme 1 and alpha hydroxylate vitamin D decrease?
what is the function?
what organ?
kidney ( 1 and alpha hydroxylate)
absorp ca and p