Complement

Question 1

How many major complement factors are there?

Answer 1

9

Question 2

What are complement factors?

Answer 2

Pro-enzymes present in normal serum hat are not increased by antigenic stimulation

Question 3

What are the three complement pathways?

Answer 3

1) Classical
2) Alternate
3) Mannan-binding lectin pathway

Question 4

Which pathway/pathways act independent of antibody?

Answer 4

The alternate pathway and the mannan-binding lectin pathway

Question 5

What antibodies are involved in the classical pathway?

Answer 5

Either IgM or a doublet of IgG1, IgG2, or IgG3

Question 6

What antibody can be involved in the alternate pathway?

Answer 6

IgA

Question 7

Initiating factor in the classical pathway

Answer 7

C1qrs/C1q

Question 8

Initiating factor in the alternate pathway

Answer 8

C3b

Question 9

Initiating factor for mannan-binding lectin pathway

Answer 9

mannose binding lectin (MBL)

Question 10

Which pathway uses all 9 factors?

Answer 10

only the classical pathway

Question 11

Which factors are not used by the alternate pathway?

Answer 11

C1, C2, C4

Question 12

Which factors are not used by the mannose binding lectin pathway?

Answer 12

C1, because MBL acts like C1

Question 13

Which factors combine to form the membrane attack complex (MAC)?

Answer 13

C5b, C6-9

Question 14

The C3bBbC3b/C3bBb complexes are associated with which pathway?

Answer 14

alternate

Question 15

Factors B and D are associated with which pathway?

Answer 15

alternate

Question 16

MAC is associated with which pathways?

Answer 16

All three pathways

Question 17

properdin is associated with which pathway?

Answer 17

alternate

Question 18

Which complement factors act as chemotactic adjuncts?

Answer 18

C3a and C5a

Question 19

Which complement factors promote opsonization by binding to microoganisms?

Answer 19

C3b