Cell-mediated immunity

Question 1

what do T cells need to do to survive positive (primary) selection in the thymus?

Answer 1

• engage with either MHC I or MHC II

- if they don’t engage they apoptose

Question 2

What do T cells need to do to survive negative (secondary) selection in the thymus?

Answer 2

• they need to NOT recognize self peptide on either MHC I or MHC II

Question 3

Positive T cell selection happens in the:

Answer 3

Cortex of the thymus

Question 4

Negative T cell selection happens in the

Answer 4

Medulla of the thymus

Question 5

T cell anergy can be induced in two ways:

Answer 5

1) lack of second signal or signal inhibition

2) active engagement of inhibitory receptors (CTLA-4)