Adaptive immunity Flashcards
Cells involved in cell mediated immunity
cytotoxic T cells, NK cells, macrophages
What are the central lymphoid organs and what happens there?
1) Thymus and bone marrow
2) Immunocompetent cells are developed
What are the peripheral lymphoid organs and what happens there?
1) spleen, lymph nodes, tonsils, Peyer’s patches
2) immunocompetency is expressed
Two major markers of all T cells
CD2 and CD3
Major marker of T helper cells
CD4
Major marker of cytotoxic T cells
CD8
Major expression changes when T cell leaves thymus?
acquisition of TCR-CD3 complex, loss of CD1
3 things Th1 cells secrete:
IL-2, IFN-gamma, TNF-a
5 things Th2 cells secrete:
IL-4, 5, 6, 10, 13
Multiple actions of Th1 cells
- activation of B cells
- activation of cytotoxic T cells
- activation of Th cells
- activation of APCs
- down regulation of Th2 cell functions
- increased CMI
Multiple actions of Th2 cells
- B cell differentiation and proliferation
- activation of eosinophils
- down regulation of Th1 cell functions
- class switching
- increased antibody
Mature B cells are activated by:
IL-2, 4, 5, 6 from T cells
What three types of cells can be professional APCs?
dendritic cells, B cells, macrophages
The TAP protein is associated with what type of presentation?
MHC I presentation to CD8 T cells
The CLIP protein is associated with what type of presentation?
MHC II presentation to CD4 T cells
