Competitive and Noncompetitive inhibition Flashcards
Competitive inhibition
substrate and inhibitor have similar structures: for this reason there will be a competition between the substrate and the inhibiton for the active side of the enzyme
cause the enzyme is not able to bind on both on the same time
the inhibitor will bind on the enzyme, not on the enzyme substrate complex
KM modified
=> increases
Noncompetitive inhibition
the substrate and the inhibitor have different structures - no competition betweem them
the substrate will be bound to the active side of the enzyme, the inhibitor will bound to another site of the enzyme (regulatory side)
the inhibitor binds to the enzyme but on the same time also to the enzyme substrate complex
Vmax modified => decreaes
In hepatic cirrhosis the activity of serum cholinesterase is…
decreased
The normal value of serum amylase is…
60 - 300 U/L
In a bilary tract obstruction the activity of serum GGT is…
increased
The formula for Lineweaver-Burk equation is…
represents the linear form of Michaelis-Menton equation and is used to determine KM and VMax
1/KM = obtained the point where the straight line intercepts the axis line (horizonatal axis)
1/VMAX = obtained in the point where the straight line intercepts the y axis (vertical axis)
Role of Acetylcholine is…
an important neurotransmitter
