Communicable Diseases Flashcards

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1
Q

What is a pathogen?

A

An organism which causes disease

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2
Q

Passive Physical plant defences

A

Cellulose cell wall - physical barrier

Lignin cell wall - waterproof, almost indigestible

Bark - contains chemicals to defend against pathogens

Waxy cuticle - prevents water collecting on the cell surfaces, creates absence of water which pathogens need to survive

Closed stomata - when pathogen detected to prevent pathogens entering

Callose - deposited around sieve plates and blocks flow in sieve tube, preventing spread of pathogens

Tylose - plugs xylem vessel, preventing water flow and blocks pathogen, contains toxins to pathogens

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3
Q

Passive Plant chemical defences

A

Plant tissues - contain anti pathogenic properties e.g terpenoids, or phenols, alkaloids, hydrolytic enzymes

Terpenes in tyloses and tannins in bark are present before infection

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4
Q

Why are chemical defences made after the infection is detected in plants?

A

Production of chemicals requires lots of energy

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5
Q

Active physical plant defences

A

Cell wall - becomes thickened and strengthened with cellulose

Oxidative bursts - produce highly reactive oxygen molecules to damage pathogen cells

Callose - deposited between plant cell wall and cell membrane to prevent cell penetration

Necrosis - deliberate cell suicide

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6
Q

How does Mycobacterium tuberculosis cause disease?

A

Triggers response by infecting phagocytes in the lungs

Infected phagocytes are sealed in waxy coated tubercles so bacteria remains dormant

If another factor weakens immune system, bacteria becomes active and destroys lung tissue

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7
Q

How does HIV result in aids?

A

Attachment proteins bind to complementary CD4 receptors

HIV particles replicate inside cells killing or damaging them

AIDS develops when there are too few Th cells for immune system to function

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8
Q

Describe 3 fungal infections

A

Black Sigatoka

Ring worm

Athletes foot

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9
Q

How are communicable pathogens transmitted directly?

A

Inhalation

Skin to skin contact

Passively through wounds

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10
Q

Hoe are communicable pathogens transmitted indirectly?

A

Consumption of contaminated food

Via a vector

Spores

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11
Q

4 physical barriers to pathogens in plants

A

Cellulose cell walls

Lignified layer

Waxy upper cuticle

Old vascular tissue is blocked to prevent pathogens spreading inside plant

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12
Q

2 mechanical responses to pathogens in plants

A

Guard cells close stomata

Thick polysaccharide Callose depositors between cell wall and plasma membrane to limit spread

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13
Q

Describe chemical defences plants use against pathogens

A

Terpenoids (essential oils) e.g methols act as antibacterials

Phenols e.g tannin inhibit insects from attacking by interfering with digestion

Alkaloids e.g caffeine and morphins deter herbivores from feeding due to bitter taste

Defensins inhibit transport channels

Hydrolytic enzymes e.g chitinases which break down cell wall of invading organisms

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14
Q

5 barriers to infection in animals

A

Skin is a tough keritinised layer

Blood clotting prevents access through cuts

Hydrochloric acid in stomach kills bacteria

Harmless bacteria in gut which increases interspecific competition with pathogens

Mucous membranes to trap pathogens

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15
Q

Name 4 ways the non specific immune system responds to infection

A

Inflammation

Phagocytosis

Digestive action of lysosomes

Production of antiviral agents

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16
Q

Outline the process of inflammation

A

Damaged vessels release histamines, causing vasodilation

Blood flow and permeability of blood vessels increase

White blood cells and plasma move to infected tissue

17
Q

How does blood clotting occur?

A

Blood platelets plug and release chemicals to enhance clotting e.g thromboplastin

Prothrombin changes into thrombin by thrombokinase

Fibrinogen changed to insoluble fibrin which covers wound

18
Q

Name 2 types of white blood cell involved in phagocytosis

A

Neutrophils

Macrophages (can become antigen presenting cells)

19
Q

How does phagocytosis destroy pathogens?

A

Phagocyte engulfs the pathogen by endocytosis to form a phagosome

Phagosome fuses with lysosome

Lysosome digests pathogen through hydrolysis leaving amino acids

Phagocyte then absorbs the products

20
Q

Explain the role of antigen presenting cells

A

Macrophage display antigen from pathogen on its surface

Enhances recognition by Th cells which cannot directly interface with pathogens

Secrete cytokines which stimulate specific immune response

21
Q

What is an antibody? Describe its structure

A

Proteins secreted by plasma cells

2 light chains held by disulphide bridges, 2 longer heavy chains. 4 polypeptide chains

Binding sites on variable region of light chains have specific tertiary structure which is complementary to an antigen

The rest is the constant region which binds to phagocytes

22
Q

How do antibodies lead to the destruction of a pathogen?

A

Agglutination from antigen antibody complexes to enhance phagocytosis

Activation of a complement

Opsonises mark microbes for phagocytes

Antitoxins make toxins insoluble

23
Q

Compare passive and active immunity

A

Passive
- no memory cells and antibodies not replaces so is short term
- immediate
- antibodies from external source
- no direct contact with antigen needed

Active
- memory cells produced so long term
- time lag
- lymphocytes produce antibodies
- needs direct contact with antigen

24
Q

Examples of passive and natural immunity

A

Passive neutral - antibodies in breast milk / placenta

Passive artificial - anti venom, needle stick injections

Active natural - humoral response to infection

Active artificial - vaccination

25
Q

What are neutrophils and their characteristics?

A
  • most common
  • multi lobed nucleus
  • made in bone marrow
  • contain lysosomes
  • engulf and digest pathogens
26
Q

What are macrophages and their characteristics?

A
  • less common
  • travel in blood as monocytes
  • indicate specific response to pathogens
  • more mature
  • mostly in lymph nodes
  • antigen from pathogen forms a special protein complex on surface of the cell becoming an APS
  • displays antigens for other immune cells to recognise
  • presented with MHC II cells so recognised as ‘self cells’
27
Q

What is the role of B cells in a specific immune response?

A

Make antibodies

28
Q

Where are B cells produced?

A

Bone marrow

29
Q

What is the role of T cells?

A

Destroy infected body cells

30
Q

Where are T cells produced?

A

Produced in the thymus

31
Q

What are the two types of B cells and what do they do?

A

Plasma B cell - circulate in the blood making and releasing antibodies

Memory B cells - remain in the body for years as immunological memory

32
Q

What are the 4 types of T cell and what are their roles?

A

Killer T cell (cytotoxic) - kill infected body cells

Helper T cells - release cytokines to stimulate B cell development and stimulate phagocytes

Memory T cell - stay in blood and differentiate into Tk or Th cells in reinfection

Regulator T cells - shut down immune response after pathogen neutralised to prevent auto immunity