Common Autoantibodies

Question 1

Rheumatoid Factor (4)

Answer 1

RA, SLE, Sjogren’s, mixed connective tissue disease

Question 2

Anti-cyclic citrullinated peptide 2

Answer 2

Rheumatoid Arthritis

Question 3

ANA (7)

Answer 3

Drug-induced lupus, SLE, scleroderma, Sjogren’s, MCTD, polymyositis/dermatomyositis, RA

Question 4

Anti-dsDNA

Answer 4

Very specific for SLE

Question 5

Antihistone

Answer 5

Drug-induced lupus

Question 6

Anti-sm

Answer 6

Very specific for SLE

Question 7

Anti-Ro/Anti-La

Answer 7

Sjogren’s

Question 8

Antiphospholipid

Answer 8

Primary antiphospholipid syndrome

Question 9

Anticentromeric

Answer 9

Scleroderma

Question 10

Anti-topo-I (anti-Scl-70)

Answer 10

Scleroderma

Question 11

Anti-Jo1

Answer 11

Polymyositis/dermatomyositis

Question 12

Anti-thyroid peroxidase

Answer 12

Hashimoto’s

Question 13

Anti-smooth muscle

Answer 13

Autoimmune Hepatitis

Question 14

Antimitochondrial

Answer 14

Primary biliary cirrhosis

Question 15

c-ANCA

Answer 15

Wegener’s granulomatosis

Question 16

p-ANCA

Answer 16

Vasculitis, microscopic polyangitis

Question 17

Anti-GBM

Answer 17

Goodpasteure’s

Question 18

Antitransglutaminase

Answer 18

Celiacs

Question 19

Complement C3/C4 (decreased levels)

Answer 19

SLE, cryoglobulinemia

Question 20

antitopoisomerase

Answer 20

scleroderma

Question 21

Anti-TSHR

Answer 21

Graves Disease

Question 22

U1RNP antibody

Answer 22

MCTD