Combined oral contraceptive pill (Complete) Flashcards
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What does the combined oral contraceptive pill contain?
Progesterone
Oestrogen
Combined oral contraceptive pill is also referred to as?
Combined hormonal contraception (CHC)
What are the 3 main routes of administration for CHC?
Orally
Transdermally
Intravaginally
What is the mechanisms of action of CHC?
Involves:
Thickening the cervical mucus
Thinning the endometrium
Inhibiting ovulation
What are the contraindictions for taking CHC?
Anything that increases risk of venous thromboembolism such as:
Migarine with aura
Less than 6 weeks post-partum for breastfeeding woman
Cardiomyopathy
AF
Active breast cancer
Antiphospholipid antibodies
Age >35 years and smoking >15 cigarettes a day
Hypertension ( ≥160 mmHg systolic or ≥100 mmHg diastolic)
Vascular disease
IHD
Hx of CVA (e.g. TIA)
Hx VTE
Major surgery with prolonged immobilisation
Known thrombogenic disorders (E.g. factor V lieden)
Complex valvular heart disease (e.g. pulmonary hypertension, history of subacute bacterial endocarditis)
Severe liver cirrhosis
Hepatocellular adenoma or carcinoma
Why is CHC contraindicted in breast-feeding woman less than 6 weeks post-partum?
Due to:
Increased risk of thromboembolism post-partum
Reduction in lactation
Can be transferred to milk
Why is migraine with aura a contraindiction for CHC?
Migraine with aura involves neurogenic inflammation and activation of thrombotic pathways
What are the three main types of combined oral contraceptive pill? (COCP)
Monophasic: Each pill contains same dose
Phasic: Pills contain differing amounts of hormones and must be taken in the correct order
Every day pills: contain 21 hormone-containing pills, and 7 hormone-free pills
What regimens are available for CHC?
Traditional
Extended
Continuous use
Flexible-extended use
What is the traditional regiment for CHC?
Pill: One pill per day for 3 weeks followed by 7 day hormone free interval (HFI)
Patch: One patch per week for 3 weeks followed by 7 day HFI
Intravaginal: one vaginal ring for 3 weeks followed by 7-day HFI
What is extended use regimen for CHC?
Used for a period of nine weeks (3 months), followed by a 7-day HFI, also known as “tricycling”
What is continous use regimen for CHC?
Used continuously without any HFI
What is flexible extended use regimen?
Method used until breakthrough bleed followed by 4-day HFI
What information needs to be relayed to the patient when starting COCP?
If started on first day of period will provide immediate contraceptive protection.
If started at any other time in cycle, need 7 days of additional protection (e.g. condoms).
Postpartum patients can begin 21 days after giving birth unless they are breastfeeding which would be 6 weeks.
What are the advantages of CHC? (8)
- Effective (failure rate < 1 per 100 woman years)
- Doesn’t interfere with sex
- Contraceptive effects revisible upon stopping
- Makes periods regular, lighter and less painful
- Reduces risk of ovarian and endometrial cancers which can last for decades affter stopping.
- Reduces risk of colorectal cancer
- Can protect against PID (pelvic inflammatory disease)
- Reduces ovarian cysts, benign breast disease and acne vulgaris