Collagen, Elastin and Keratin Flashcards

1
Q

type 1 collagen, 2, 3 and 4

A

Skin
Connective Tissue
Arteries
Basement Membrane

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2
Q

N acetylation occurs in what structure

A

RER

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3
Q

chaperone that takes things through the golgi

A

HSP 90

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4
Q

chaperone that takes things through the lysosome

A

HSP 70

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5
Q

what is added to amino terminals of proteins while in the RER to take them to the mitochondria

A

short amino terminal sequence

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6
Q

what kind of DNA is circular

A

mitochondrial

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7
Q

mitochondrial problem that cause fatigue but a normal life is seen

A

Leighs DIsease

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8
Q

mitochondrial disease in which there is blindness shortly after birth

A

Leibers optic degeneration

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9
Q

which protein does not have a degraded pro sequence

A

Insulin

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10
Q

what has to happen to tropocollagen before it can become collage

A

it must be cleaved by plasma peptidases

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11
Q

desmoplasia

A

this is when collagen surrounds a tumor

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12
Q

retinal detachment seen in Marfan syndrome

A

from the bottom so the patient will look up

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13
Q

multiple infarcts as a child
marfanoid features
high amounts of urinary methionine

A

homocystienuria

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14
Q

HLA B27 problem where there is bamboo spine in middle aged men and the die from aortic dissection

A

ankylosing spondylitis

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15
Q

tree bark appearance due to attacks of the vasovasorum in the aorta

A

tertiary syphillis

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16
Q

reactive arthritis is caused by what things

A
chlamydia
yersina
campylobacter
shigella
IBD
17
Q

granulomas chewing away at the aorta until dissection in young asian women

A

takyasu disease

18
Q

anti centromere

19
Q

anti smooth AB and anti SCL-70

A

scleroderma

20
Q

anti-topoisomerase AB

A

progressive systemic sclerosis

21
Q

citrullinated plasma protein is a marker for this

22
Q

RA, leukopenia and splenomegaly

A

Felty Syndrome

23
Q

RA, GI ulcers and uveitis

A

Behcet’s syndrome

24
Q

xerostomia and xerophthalamia

A

sjogre’s Syndrome

25
anti smith, cardiolipin and dsDNA
SLE
26
Anti Ro, La SS-A and SS-B
sjogrens syndrome
27
tx for SLE
mycophenalate and cyclophosphamide
28
tx for RA
methotrexate
29
Anti Ribonucleic Protein
MCTD
30
elastin has desmosine what is that
lysine lined up two by two with positive charges repelling each other
31
alpha 1 antitrypsin inhibits what
elastase
32
alpha one antitrypsin decreases with what
aging
33
4 types of emphysema
panacinar - alpha1 antitrypsin centroacinar- smoking distoacinar-aging bulluos- staph aureus and pseudomonas
34
4 types of patients that you have to be afraid for staph aureus and pseudomonas
neutropenic burn patients cystic fibrosis diabetics
35
keratin contains a lot of what that makes it very strong
cysteine (disulfide bonds)
36
elastase cuts to the right of what
glycine serine arginine