Collagen, Elastin and Keratin

Question 1

type 1 collagen, 2, 3 and 4

Answer 1

Skin
Connective Tissue
Arteries
Basement Membrane

Question 2

N acetylation occurs in what structure

Answer 2

RER

Question 3

chaperone that takes things through the golgi

Answer 3

HSP 90

Question 4

chaperone that takes things through the lysosome

Answer 4

HSP 70

Question 5

what is added to amino terminals of proteins while in the RER to take them to the mitochondria

Answer 5

short amino terminal sequence

Question 6

what kind of DNA is circular

Answer 6

mitochondrial

Question 7

mitochondrial problem that cause fatigue but a normal life is seen

Answer 7

Leighs DIsease

Question 8

mitochondrial disease in which there is blindness shortly after birth

Answer 8

Leibers optic degeneration

Question 9

which protein does not have a degraded pro sequence

Answer 9

Insulin

Question 10

what has to happen to tropocollagen before it can become collage

Answer 10

it must be cleaved by plasma peptidases

Question 11

desmoplasia

Answer 11

this is when collagen surrounds a tumor

Question 12

retinal detachment seen in Marfan syndrome

Answer 12

from the bottom so the patient will look up

Question 13

multiple infarcts as a child
marfanoid features
high amounts of urinary methionine

Answer 13

homocystienuria

Question 14

HLA B27 problem where there is bamboo spine in middle aged men and the die from aortic dissection

Answer 14

ankylosing spondylitis

Question 15

tree bark appearance due to attacks of the vasovasorum in the aorta

Answer 15

tertiary syphillis

Question 16

reactive arthritis is caused by what things

Answer 16

chlamydia
yersina
campylobacter
shigella
IBD

Question 17

granulomas chewing away at the aorta until dissection in young asian women

Answer 17

takyasu disease

Question 18

anti centromere

Answer 18

CREST

Question 19

anti smooth AB and anti SCL-70

Answer 19

scleroderma

Question 20

anti-topoisomerase AB

Answer 20

progressive systemic sclerosis

Question 21

citrullinated plasma protein is a marker for this

Answer 21

RA

Question 22

RA, leukopenia and splenomegaly

Answer 22

Felty Syndrome

Question 23

RA, GI ulcers and uveitis

Answer 23

Behcet’s syndrome

Question 24

xerostomia and xerophthalamia

Answer 24

sjogre’s Syndrome

Question 25

anti smith, cardiolipin and dsDNA

Answer 25

SLE

Question 26

Anti Ro, La SS-A and SS-B

Answer 26

sjogrens syndrome

Question 27

tx for SLE

Answer 27

mycophenalate and cyclophosphamide

Question 28

tx for RA

Answer 28

methotrexate

Question 29

Anti Ribonucleic Protein

Answer 29

MCTD

Question 30

elastin has desmosine what is that

Answer 30

lysine lined up two by two with positive charges repelling each other

Question 31

alpha 1 antitrypsin inhibits what

Answer 31

elastase

Question 32

alpha one antitrypsin decreases with what

Answer 32

aging

Question 33

4 types of emphysema

Answer 33

panacinar - alpha1 antitrypsin
centroacinar- smoking
distoacinar-aging
bulluos- staph aureus and pseudomonas

Question 34

4 types of patients that you have to be afraid for staph aureus and pseudomonas

Answer 34

neutropenic
burn patients
cystic fibrosis
diabetics

Question 35

keratin contains a lot of what that makes it very strong

Answer 35

cysteine (disulfide bonds)

Question 36

elastase cuts to the right of what

Answer 36

glycine
serine
arginine