Collagen, Elastin and Keratin Flashcards
type 1 collagen, 2, 3 and 4
Skin
Connective Tissue
Arteries
Basement Membrane
N acetylation occurs in what structure
RER
chaperone that takes things through the golgi
HSP 90
chaperone that takes things through the lysosome
HSP 70
what is added to amino terminals of proteins while in the RER to take them to the mitochondria
short amino terminal sequence
what kind of DNA is circular
mitochondrial
mitochondrial problem that cause fatigue but a normal life is seen
Leighs DIsease
mitochondrial disease in which there is blindness shortly after birth
Leibers optic degeneration
which protein does not have a degraded pro sequence
Insulin
what has to happen to tropocollagen before it can become collage
it must be cleaved by plasma peptidases
desmoplasia
this is when collagen surrounds a tumor
retinal detachment seen in Marfan syndrome
from the bottom so the patient will look up
multiple infarcts as a child
marfanoid features
high amounts of urinary methionine
homocystienuria
HLA B27 problem where there is bamboo spine in middle aged men and the die from aortic dissection
ankylosing spondylitis
tree bark appearance due to attacks of the vasovasorum in the aorta
tertiary syphillis
reactive arthritis is caused by what things
chlamydia yersina campylobacter shigella IBD
granulomas chewing away at the aorta until dissection in young asian women
takyasu disease
anti centromere
CREST
anti smooth AB and anti SCL-70
scleroderma
anti-topoisomerase AB
progressive systemic sclerosis
citrullinated plasma protein is a marker for this
RA
RA, leukopenia and splenomegaly
Felty Syndrome
RA, GI ulcers and uveitis
Behcet’s syndrome
xerostomia and xerophthalamia
sjogre’s Syndrome
anti smith, cardiolipin and dsDNA
SLE
Anti Ro, La SS-A and SS-B
sjogrens syndrome
tx for SLE
mycophenalate and cyclophosphamide
tx for RA
methotrexate
Anti Ribonucleic Protein
MCTD
elastin has desmosine what is that
lysine lined up two by two with positive charges repelling each other
alpha 1 antitrypsin inhibits what
elastase
alpha one antitrypsin decreases with what
aging
4 types of emphysema
panacinar - alpha1 antitrypsin
centroacinar- smoking
distoacinar-aging
bulluos- staph aureus and pseudomonas
4 types of patients that you have to be afraid for staph aureus and pseudomonas
neutropenic
burn patients
cystic fibrosis
diabetics
keratin contains a lot of what that makes it very strong
cysteine (disulfide bonds)
elastase cuts to the right of what
glycine
serine
arginine
