Coeliac Disease

Question 1

What is coeliac disease

Answer 1

Autoimmune condition when exposure to gluten causes an immune rection, creating inflammation in small intestine. Atrophy of intestinal villi

Question 2

Presentation of coeliac disease

Answer 2

Failure to thrive, diarrhoea, fatigue, mouth ulcers, weight loss, anaemia, dermatitis, herpetiformis

Question 3

Associations with coeliac disease

Answer 3

Type 1 diabetes, also linked with thyroid disease, autoimmune hepatitis, primary biliary cirrhosis, PSC, Downs

Question 4

Which gene is responsible

Answer 4

HLA-DQ2 (90%)

Question 5

Who else is tested if child is diagnosed

Answer 5

All first degree relatives are tested

Question 6

Diagnosis of coeliac disease

Answer 6

Anti-TTG antibodies
Endomysial antibodies
Deaminated gliadin peptide antibodies (anti-DGPs)
All checked while on gluten diet
Exclude IgA deficiency

Question 7

Complications of coeliac disease

Answer 7

Vitamin deficiency
Anaemia
Osteoporosis
Ulcerated jejunitisenteropathy-associated T cell lymphoma of the intestine
Non-hodgkin lymphoma
Small bowel adenocarcinoma

Question 8

Treatment of coeliac disease

Answer 8

Life long gluten free diet
Checking coeliac antibodies over time and they should decrease if there is good response