Coeliac Disease Flashcards
1
Q
What is the definition of coeliac disease?
A
Coeliac disease is a systemic autoimmune disorder that affects the small intestine and is triggered by the ingestion of gluten peptides found in wheat, barley, rye and other related grains. Malabsorption is the hallmark of coeliac disease.
2
Q
What are some risk factors of coeliac disease?
A
- Family history
- HLA-DQ2 and HLA-DQ8
- Autoimmunity: type 1 diabetes, autoimmune thyroid disease and autoimmune hepatitis
- IgA deficiency: allows increased gluten peptides to circulate in the submucosa
- Down’s syndrome
- Turner’s syndrome
3
Q
What are the symptoms and signs of coeliac disease?
A
- Indigestion
- Diarrhoea (watery) or steatorrhoea (pale, floating stools)
- Abdominal bloating or discomfort
- Constipation
- Prolonged fatigue
- Weight loss
- Severe/persistent mouth ulcers
- Growth issues in children
4
Q
What is the best first-line investigation for coeliac disease?
A
Anti IgA-tTG
