Coagulopathies (Haemostasis disorders) Flashcards
1
Q
Von Willebrand Disease (VWD)
A
2
Q
Type 1 Von Willebrand Disease (VWD)
A
3
Q
Type 2 Von Willebrand Disease (VWD)
A
4
Q
Type 3 Von Willebrand Disease (VWD)
A
5
Q
Lab Diagnosis: Von Willebrand Disease (VWD)
A
6
Q
Treatment: Von Willebrand Disease (VWD)
A
7
Q
Haemophilia
A
8
Q
Lab Diagnosis: Haemophilia
A
9
Q
Treatment: Haemophilia
A
10
Q
Haemophilia A
A
11
Q
Haemophilia B
A
12
Q
Haemophilia C
A
13
Q
FII Def
A
14
Q
FV Def
A
15
Q
FVII Def
A
16
Q
FX Def
A
17
Q
FXI Def
A
18
Q
FXII Def
A
19
Q
FXIII Def
A
20
Q
Vitamin K def
A
21
Q
Liver disease affecting coagulation
A
22
Q
DIC - Disseminated Intravascular Coagulation
A
23
Q
what initiates the coagulation cascade IN VIVO?
A
tissue factor (TF)
24
Q
what does von Willebrand factor do?
A
binds platelets to the phosphlipid surface
25
3A 4E 5C 6B 7A 8CandE 9A 10C 11ABC 12B
1 B 1 6A 71 8C 91 101 11AandD 12A
26
What is the most common inherited bleeding disorder?
von Willebrand disease
27
which part of the coag cascade is activated first?
extrinsic activated first by tissue factor from trauma, then the intrinsic is activated later
28
what anti-clotting substance acts on factors V and VIII?
Protein C
29
what are the 3 cofactors in the 3 tenase complexes?
Intrinsic = VIIIa
Extrinsic = TF
Common = Va
30
What are the ingredients in a PT test?
plasma sample
+ phospholipid
+ calcium
31
Which test evaluates the extrinsic pathway?
PT
32
Which test evaluates the intrinsic pathway?
APTT
33
both VW disease and Haemophilia A show factor-type A bleeding. what is this?
34
why may VWD have a normal PPT?
35
why may Factor V def have a normal PPT?
36
which factor deficiency doesnt lead to bleeding but prolongs APTT?
XII (12)
37
