Coagulopathies (Haemostasis disorders)

Question 1

Von Willebrand Disease (VWD)​

Question 2

Type 1 Von Willebrand Disease (VWD)​

Question 3

Type 2 Von Willebrand Disease (VWD)​

Question 4

Type 3 Von Willebrand Disease (VWD)​

Question 5

Lab Diagnosis: Von Willebrand Disease (VWD)​

Question 6

Treatment: Von Willebrand Disease (VWD)​

Question 7

Haemophilia

Question 8

Lab Diagnosis: Haemophilia

Question 9

Treatment: Haemophilia

Question 10

Haemophilia A

Question 11

Haemophilia B

Question 12

Haemophilia C

Question 13

FII Def

Question 14

FV Def

Question 15

FVII Def

Question 16

FX Def

Question 17

FXI Def

Question 18

FXII Def

Question 19

FXIII Def

Question 20

Vitamin K def

Question 21

Liver disease affecting coagulation

Question 22

DIC - Disseminated Intravascular Coagulation

Question 23

what initiates the coagulation cascade IN VIVO?

Answer 23

tissue factor (TF)

Question 24

what does von Willebrand factor do?

Answer 24

binds platelets to the phosphlipid surface

Question 25

3A 4E 5C 6B 7A 8CandE 9A 10C 11ABC 12B

Answer 25

1 B 1 6A 71 8C 91 101 11AandD 12A

Question 26

What is the most common inherited bleeding disorder?

Answer 26

von Willebrand disease

Question 27

which part of the coag cascade is activated first?

Answer 27

extrinsic activated first by tissue factor from trauma, then the intrinsic is activated later

Question 28

what anti-clotting substance acts on factors V and VIII?

Answer 28

Protein C

Question 29

what are the 3 cofactors in the 3 tenase complexes?

Answer 29

Intrinsic = VIIIa
Extrinsic = TF
Common = Va

Question 30

What are the ingredients in a PT test?

Answer 30

plasma sample
+ phospholipid
+ calcium

Question 31

Which test evaluates the extrinsic pathway?

Answer 31

PT

Question 32

Which test evaluates the intrinsic pathway?

Answer 32

APTT

Question 33

both VW disease and Haemophilia A show factor-type A bleeding. what is this?

Question 34

why may VWD have a normal PPT?

Question 35

why may Factor V def have a normal PPT?

Question 36

which factor deficiency doesnt lead to bleeding but prolongs APTT?

Answer 36

XII (12)