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Hematology 2 > Coagulaton Tests and Fibrinolysis > Flashcards

Coagulaton Tests and Fibrinolysis Flashcards

1
Q

Manual techniques

A

Tilt tube, wire loop

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2
Q

REQUIRES GENTLE TILTING OF THE TUBE BACK AND FORTH AT THE RATE OF ABOUT ONCE PER SECOND UNTIL A FIBRIN WEB IS FORMED.

A

TILT TUBE METHOD

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3
Q

EMPLOYS THE USE OF A WIRE LOOP THAT IS PASSED THROUGH THE MIXTURE AT THE RATE OF TWO SWEEPS PER SECOND UNTIL A FORMED
CLOT ADHERES TO THE LOOP.

A

NICHROME WIRE LOOP TECHNIQUE

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4
Q

Automated techniques

A

MOVING PROBE, OPTICAL DENSITY

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5
Q

A CLOT IS DETECTED EITHER BY USE OF A ______ IMMERSED IN THE MIXTURE THAT IS TRIGGERED BY CLOT FORMATION

A

MOVING PROBE

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6
Q

A CLOT IS DETECTED EITHER BY USE OF A MOVING PROBE OR BY THE CHANGE IN ____ OF THE MIXTURE WHEN A CLOT FORMS.

A

OPTICAL DENSITY

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7
Q

SCREEN SECONDARY HEMOSTASIS
(INTRINSIC AND COMMON PATHWAY)

A

LEE AND WHITE METHOD

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8
Q

LEE AND WHITE METHOD principle

A

EXPOSE BLOOD TO A NEGATIVELY CHARGED SURFACE

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9
Q

NV FOR LEE AND WHITE METHOD

A

5-15 min

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10
Q

The surface of the glass tube initiates the Clotting process. This test is sensitive to the factors involved in the intrinsic pathway

A

Clotting Time - Slide Method
(Intrinsic)

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11
Q

The expected range for Slide Method Clotting Time is

A

4-10 min.

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12
Q

LABORATORY SCREENING

A

• PROTHROMBIN TIME
• ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT)

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13
Q

IS A USEFUL SCREENING PROCEDURE FOR THE EXTRINSIC AND COMMON PATHWAY.

A

PROTHROMBIN TIME

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14
Q

Sample for PROTHROMBIN TIME

A

CITRATED PLASMA

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15
Q

REAGENT: PROTHROMBIN TIME

A

TISSUE THROMBOPLASTIN
0.025 MOL/L SOLUTION OF CALCIUM CHLORIDE.

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16
Q

NORMAL RANGE: PROTHROMBIN TIME

A

10-15 SEC

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17
Q

MEASURES ALL FACTORS IN THE INTRINSIC
AND COMMON PATHWAY EXCEPT FACTOR XIII (fibrin stabilizing) AND PLATELETS.

A

ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT)

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18
Q

ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) SAMPLE:

A

CITRATED PLASMA

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19
Q

ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) REAGENT:

A

PARTIAL THROMBOPLASTIN, CALCIUM CHLORIDE, ACTIVATORS

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20
Q

ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) ACTIVATORS:

A

SILICA, KAOLIN, ELLAGIC ACID, CELITE

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21
Q

ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) NORMAL RANGE:

A

28-46 SEC

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22
Q

MEASURES THE AVAILABILITY OF FUNCTIONAL FIBRINOGEN OR DECREASED AMOUNT (75-100 MG/DL). AFFECTED BY HEPARIN.

A

THROMBIN TIME (TT)

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23
Q

THROMBIN TIME (TT) PRINCIPLE:

A

MEASURED THROMBIN IS ADDED TO PLASMA AND TIME FOR FIBRIN CLOT
FORMATION IS RECORDED.

24
Q

FIBRINOGEN DECREASED AMOUNT

A

(75-100 MG/DL).

25
Q

THROMBIN TIME (TT)

A

10-14 SEC (BROWN)

26
Q

Thrombin time is affected by

A

Heparin

27
Q

SAME AS THROMBIN TIME BUT NOT AFFECTED BY HEPARIN.

A

REPTILASE TIME

28
Q

IS AN ENZYME FOUND IN THE VENOM OF THE BOTHROPS ATROX SNAKE THAT CAN CONVERT FIBRINOGEN O FIBRIN.

A

REPTILASE (ATROXIN)

29
Q

SNAKE THAT CAN CONVERT FIBRINOGEN O FIBRIN.

A

BOTHROPS ATROX SNAKE

30
Q

TIME IS RECORDED AS CLOT IS FORMED AFTER REPTILASE IS ADDED TO PLASMA.

A

REPTILASE TIME

31
Q

REPTILASE TIME NV

A

10-15 SEC

32
Q

USED TO DETECT DEFICIENCIES OF THE COMMON PATHWAY (FACTORS X, V, II AND I)

A

STYPVEN TIME (RUSSELL’S VIPER VENOM TIME)

33
Q

IS A THROMBOPLASTIN LIKE SUBSTANCE THAT ACTIVATES FACTOR X.

A

STYPVEN

34
Q

STYPVEN TIME (RUSSELL’S VIPER VENOM TIME) NV:

A

6-10 SEC

35
Q

COMMON PATHWAY FACTORS

A

(FACTORS X, V, |I AND I)

36
Q

DETECTS FACTOR XIII DEFICIENCY

A

DUCKERT’S TEST/ 5M UREA SOLUBILITY TEST

37
Q

IN DUCKERT’S TEST/ 5M UREA SOLUBILITY TEST CLOT FORMED AFTER COAGULATION IS ADDED WITH ___

A

5M UREA

38
Q

SUBSTITUTE FOR 5M UREA

A

• 1% MONOCHLORACETIC ACID
• 2% ACETIC ACID

39
Q

Last phase of coagulation cascade

A

Fibrinolysis

40
Q

IT IS THE SYSTEMIC,
ACCELERATING HYDROLYSIS
OF FIBRIN BY PLASMIN

A

FIBRINOLYSIS

41
Q

FIBRINOLYSIS IS THE SYSTEMIC, ACCELERATING HYDROLYSIS OF FIBRIN BY

A

PLASMIN

42
Q

Functions of plasmin

A

-Promotes Cell Migration
-Remodels ECM
-Degrades Fibrin

43
Q

‘Other Coagulation tests

A
  • Thrombin time
  • Reptilase time
  • Stypven Time (Russell’s Viper Venom Time)
    -Duckerts test / 5 M urea solubility test
44
Q

SERINE PROTEASE ZYMOGEN;

A

PLASMINOGEN

45
Q

PLASMINOGEN ACTIVE FORM WHICH DIGESTS FIBRIN AND FIBRINOGEN

A

PLASMIN

46
Q

SECRETED BY ENDOTHELIUM AND
ACTIVATES PLASMINOGEN

A

TISSUE PLASMINOGEN ACTIVATOR (TPA)

47
Q

SECRETED BY KIDNEYS AND ACTIVATES PLASMINOGEN

A

TISSUE PLASMINOGEN ACTIVATOR (TPA)

48
Q

SECRETED BY KIDNEYS AND ACTIVATES PLASMINOGEN

A

UROKINASE

49
Q

FROM ENDOTHELIUM, INHIBITS ТРА

A

PLASMNIOGEN ACTIVATOR INHIBITOR 1 (PAI-1)

50
Q

INHIBITS PLASMIN

A

A2-ANTIPLASMIN

51
Q

SUPPRESSES FIBRINOLYSIS

A

THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR

52
Q

THE FIBRIN FORMED IS COMPOSED OF TWO DOMAINS:

A

D AND E

53
Q
  1. PLASMINOGEN IN PLASMA IS ACTIVATED BY TPA AND UROKINASE INTO ACTIVE ENZYME
    ____
A

PLASMIN

54
Q
  1. PLASMIN, THEN CLEAVES THE PEPTIDE BONDS ON THE ___ AND ___ AMINO ACID THAT CONNECTS THE TWO DOMAINS.
A

ARGININE AND LYSINE

55
Q
  1. THE FIBRIN DIGESTED WILL THEN FORM THE FIBRIN DEGRADATION PRODUCTS (FDPS)
    NAMELY:
A

FRAGMENT X (D-E-D),
FRAGMENT Y (D-E),
FRAGMENT D,
FRAGMENT E,
AND FRAGMENT D-D (D-DIMER).

Hematology 2 (8 decks)

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