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Hematology 2 > Coagulation Disorders > Flashcards

Coagulation Disorders Flashcards

1
Q

is a generalized activation of hemostasis
secondary to systemic disease

A

Disseminated Intravascular Coagulation

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2
Q

It will cause Fibrin formation and
coagulation factors and platelets will then
be consumed.

A

Disseminated Intravascular Coagulation

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3
Q

In DIC Fibrinolysis will also be Active and Result
to increased

A

FDPs such as D-Dimer

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4
Q

trigger which increases clotting would lead to

A
  • Consumption of Platelets
    -Increased Consumption of Clotting factors
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5
Q

Consumption of Platelets and Increased Consumption of Clotting factors leads to

A

Thrombus formation at the site of injury + in Microcirculation

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6
Q

Thrombus formation at the site of injury + in Microcirculation leads to

A

Hemorragic syndrome (DIC)

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7
Q

Clinical Conditions Triggering DIC

A
  • Sepsis or severe infection
  • Trauma
  • Organ destruction
  • Malignancy
  • Obstetrical calamities
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8
Q

Has AD inheritance

A

Dysfibrinogenemia, VWD

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9
Q

Has X linked inheritance

A

Hemophilia A, Hemophilia B/Christmas Disease

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10
Q

Has no bleeding tendency (AR INHERITANCE)

A

FXII Def, Fletcher Trait,
Fitzgerald Trait

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11
Q

Acute Disseminated intravascular coagulation is characterized by

A

Hypofibrinoginemia

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12
Q

Disseminated Intravascular Coagulation is prolonged in

A

Both PT and APTT

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13
Q

Von willebrand Disease

A

PT Normal, APTT Prolonged

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14
Q

Which test result would be normal in patient with dysfribrinoginemia?

A

Immunological Fibrinogen Level

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15
Q

Which of the following laboratory Findings is associated with Factor XIII deficiency?

A

Clot solubility in 5 M urea solution

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16
Q

No bleeding is observed in deficiency of which of the following factors?

A

XII

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17
Q

Which laboratory test is affected by heparin therapy?

A

Thrombin time

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18
Q

Hemophilia B is:

A

X-Linked

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19
Q

10-16 sec is the Normal range for:

A

Prothrombin Time

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20
Q

Which of the following factor will be decreased in cases of Vitamin K deficiency?
I. Christmas Factor. II. Proconvertin
III. Stuart Factor IV. Hageman Factor

A

I, II and III

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21
Q

Which of the following is a characteristic of Classic Hemophilia?

A

Mild to severe Bleeding

22
Q

Prolonged APTT, Prothrombin Time, and Bleeding Time is a result for which condition?

A

DIC

23
Q

PT: Normal, APTT: Prolonged, Bleeding Time: Increased. What is the possible condition

A

VWD

24
Q

Glanzmann Thrombasthenia:

A

PT and PT Normal

25
Q

The most frequent bleeding disorder of childhood, which can lead to life-threatening bleeding:

A

Vitamin K deficiency

26
Q

Rosenthal Syndrome

A

PT Normal, APTT Prolonged

27
Q

APTT is used to?

A

Heparin Therapy
Common Pathway

28
Q

Which of the following will be abnormal in Von Willebrand disease?

A

APTT

29
Q

Christmas Disease:

A

PT Normal, APTT Prolonged

30
Q

Fletcher factor Deficiency may be associated with:

A

Thrombosis

31
Q

The test that is commonly used to monitor warfarin therapy:

A

INR ( international normalized ratio)

32
Q

Citrated plasma for APTT and PT testing should be centrifuged at 2500 x g for:

A

15 min

33
Q

Thrombocytopenia

A

Both PT and APTT Prolonged

34
Q

The most common subtype of Classic Von willebrand disease:

A

1

35
Q

Which results are associated with Hemophilia A?

A

Prolonged APTT, Normal PT

36
Q

The prothrombin Time requires that the patient’s citrated plasma be combined with:

A

CCa++ and Thromboplastin

37
Q

Thrombophilia is associated with which of the following disorders:

A

Hyperfibrinogenemia

38
Q

Hypofibrinogenemia:

A

Both PT and APTT Prolonged

39
Q

A stabilized clot is insoluble to what reagent?

A

5 m urea

40
Q

Rosenthal Syndrome will result to a prolonged result in:

A

APTT

41
Q

Which of the following complications may occur as a result of decreased tissue factor inhibitor?

A

Increased Thrombosis Risk

42
Q

All of the following are Activators except?

A

Metagross

43
Q

Ehler-Danlos Syndrome:

A

PT and PT Normal

44
Q

Factor XIII Deficiency

A

PT and PT Normal

45
Q

The most suitable product for the treatment of Hemophilia A

A

Factor VIII concentrate

46
Q

Fibrin Monomers are increased in which of the following conditions:

A

DIC

47
Q

Therapeutic Modality for Plasma

A

FF Plasma

48
Q

Parahemophilia:

A

Both PT and APTT Prolonged

49
Q

Which characteristic describes Antithrombin?

Synthesized by Megakaryocytes
Activated by Protein C
Both
Neither

A

neither

50
Q

Intrinsic Factors (PPT)

A

12,11, 9,8

51
Q

Extrinsic clotting factors (PT)

A

(3), 7

52
Q

Common clotting factor (PT & APTT)

A

10, 5, 2,1

Hematology 2 (8 decks)

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