Coagulation Disorders Flashcards
is a generalized activation of hemostasis
secondary to systemic disease
Disseminated Intravascular Coagulation
It will cause Fibrin formation and
coagulation factors and platelets will then
be consumed.
Disseminated Intravascular Coagulation
In DIC Fibrinolysis will also be Active and Result
to increased
FDPs such as D-Dimer
trigger which increases clotting would lead to
- Consumption of Platelets
-Increased Consumption of Clotting factors
Consumption of Platelets and Increased Consumption of Clotting factors leads to
Thrombus formation at the site of injury + in Microcirculation
Thrombus formation at the site of injury + in Microcirculation leads to
Hemorragic syndrome (DIC)
Clinical Conditions Triggering DIC
- Sepsis or severe infection
- Trauma
- Organ destruction
- Malignancy
- Obstetrical calamities
Has AD inheritance
Dysfibrinogenemia, VWD
Has X linked inheritance
Hemophilia A, Hemophilia B/Christmas Disease
Has no bleeding tendency (AR INHERITANCE)
FXII Def, Fletcher Trait,
Fitzgerald Trait
Acute Disseminated intravascular coagulation is characterized by
Hypofibrinoginemia
Disseminated Intravascular Coagulation is prolonged in
Both PT and APTT
Von willebrand Disease
PT Normal, APTT Prolonged
Which test result would be normal in patient with dysfribrinoginemia?
Immunological Fibrinogen Level
Which of the following laboratory Findings is associated with Factor XIII deficiency?
Clot solubility in 5 M urea solution
No bleeding is observed in deficiency of which of the following factors?
XII
Which laboratory test is affected by heparin therapy?
Thrombin time
Hemophilia B is:
X-Linked
10-16 sec is the Normal range for:
Prothrombin Time
Which of the following factor will be decreased in cases of Vitamin K deficiency?
I. Christmas Factor. II. Proconvertin
III. Stuart Factor IV. Hageman Factor
I, II and III
Which of the following is a characteristic of Classic Hemophilia?
Mild to severe Bleeding
Prolonged APTT, Prothrombin Time, and Bleeding Time is a result for which condition?
DIC
PT: Normal, APTT: Prolonged, Bleeding Time: Increased. What is the possible condition
VWD
Glanzmann Thrombasthenia:
PT and PT Normal
The most frequent bleeding disorder of childhood, which can lead to life-threatening bleeding:
Vitamin K deficiency
Rosenthal Syndrome
PT Normal, APTT Prolonged
APTT is used to?
Heparin Therapy
Common Pathway
Which of the following will be abnormal in Von Willebrand disease?
APTT
Christmas Disease:
PT Normal, APTT Prolonged
Fletcher factor Deficiency may be associated with:
Thrombosis
The test that is commonly used to monitor warfarin therapy:
INR ( international normalized ratio)
Citrated plasma for APTT and PT testing should be centrifuged at 2500 x g for:
15 min
Thrombocytopenia
Both PT and APTT Prolonged
The most common subtype of Classic Von willebrand disease:
1
Which results are associated with Hemophilia A?
Prolonged APTT, Normal PT
The prothrombin Time requires that the patient’s citrated plasma be combined with:
CCa++ and Thromboplastin
Thrombophilia is associated with which of the following disorders:
Hyperfibrinogenemia
Hypofibrinogenemia:
Both PT and APTT Prolonged
A stabilized clot is insoluble to what reagent?
5 m urea
Rosenthal Syndrome will result to a prolonged result in:
APTT
Which of the following complications may occur as a result of decreased tissue factor inhibitor?
Increased Thrombosis Risk
All of the following are Activators except?
Metagross
Ehler-Danlos Syndrome:
PT and PT Normal
Factor XIII Deficiency
PT and PT Normal
The most suitable product for the treatment of Hemophilia A
Factor VIII concentrate
Fibrin Monomers are increased in which of the following conditions:
DIC
Therapeutic Modality for Plasma
FF Plasma
Parahemophilia:
Both PT and APTT Prolonged
Which characteristic describes Antithrombin?
Synthesized by Megakaryocytes
Activated by Protein C
Both
Neither
neither
Intrinsic Factors (PPT)
12,11, 9,8
Extrinsic clotting factors (PT)
(3), 7
Common clotting factor (PT & APTT)
10, 5, 2,1
