COAGULATIVE DISORDERS - Drugs Flashcards
Drugs used to inhibit platelet
aggregation
Antiplatelets
Most common Antiplatelets
Aspirin
Drugs used to prevent the
formation of clots
Anticoagulants
Two most common examples of
anticoagulants
heparin and warfarin.
Drug used for Monitoring PT-INR
Warfarin
Drug used to monitor aPTT
Heparin
antidote for warfarin
Vitamin K (very
slow 6-24 hrs)
Antidote for heparin
Protamine
SO4
clotting factora that is inhibited by
warfarin.
Clotting Factor X, IX,
VII, II
Drug that inhibits vitamin k reductase
Warfarin
Also known as antihemorrhagic factor
Vitamin K
Examples of Low molecular weight heparin
“Parin”
(Lovenox)
(Fragmin)
(Innohep)
Polypeptide that is closely related to
hirudin
From medicinal leeches Hirudo medicinalis
Lepirudin (Refludan)
prophylactic for the treatment (management) of thrombosis in patients with HIT (Heparin Induced
Thrombocytopenia)
Argatroban
first in a new class of pentasaccharide
anticoagulants that is purely synthetic
for prophylaxis of deep-vein thrombosis
Fondaparinux (Arixtra)
the only direct thrombin inhibitor that is orally
active
Begatran
It is also a coronary vasodilator
usually given in combination with aspirin
or warfarin; it is ineffective when used
alone.
PDE INHIBITOR
chimeric monoclonal antibody
Given IV along with heparin
Abciximab
is an example of drug that is isolated from a microorganism. It is a protein from a streptococci.
Streptokinase is obtained from a bacterial culture.
Streptokinase:
Anistreplase:
Example of Anisoylated Plasminogen Streptokinase Activator Complex.
It is a prodrug
They are Synthetic
Inhibit plasminogen activation
Aminocaproic & tranexamic acid (Hemostan)
Stops bleeding by blocking plasmin
It can inhibit streptokinase
Aprotinin
The vasopressin V2 receptor agonist
desmopressin acetate increases the
plasma concentration of von Willebrand
factor and factor VIII.
Desmopressin acetate
