COAGULATIVE DISORDERS - Drugs

Question 1

Drugs used to inhibit platelet
aggregation

Answer 1

Antiplatelets

Question 2

Most common Antiplatelets

Answer 2

Aspirin

Question 3

Drugs used to prevent the
formation of clots

Answer 3

Anticoagulants

Question 4

Two most common examples of
anticoagulants

Answer 4

heparin and warfarin.

Question 5

Drug used for Monitoring PT-INR

Answer 5

Warfarin

Question 6

Drug used to monitor aPTT

Answer 6

Heparin

Question 7

antidote for warfarin

Answer 7

Vitamin K (very
slow 6-24 hrs)

Question 8

Antidote for heparin

Answer 8

Protamine
SO4

Question 9

clotting factora that is inhibited by
warfarin.

Answer 9

Clotting Factor X, IX,
VII, II

Question 10

Drug that inhibits vitamin k reductase

Answer 10

Warfarin

Question 11

Also known as antihemorrhagic factor

Answer 11

Vitamin K

Question 12

Examples of Low molecular weight heparin

Answer 12

“Parin”
(Lovenox)
(Fragmin)
(Innohep)

Question 13

Polypeptide that is closely related to
hirudin
From medicinal leeches Hirudo medicinalis

Answer 13

Lepirudin (Refludan)

Question 14

prophylactic for the treatment (management) of thrombosis in patients with HIT (Heparin Induced
Thrombocytopenia)

Answer 14

Argatroban

Question 15

first in a new class of pentasaccharide
anticoagulants that is purely synthetic
for prophylaxis of deep-vein thrombosis

Answer 15

Fondaparinux (Arixtra)

Question 16

the only direct thrombin inhibitor that is orally
active

Answer 16

Begatran

Question 17

It is also a coronary vasodilator
usually given in combination with aspirin
or warfarin; it is ineffective when used
alone.

Answer 17

PDE INHIBITOR

Question 18

chimeric monoclonal antibody
Given IV along with heparin

Answer 18

Abciximab

Question 19

is an example of drug that is isolated from a microorganism. It is a protein from a streptococci.
Streptokinase is obtained from a bacterial culture.

Answer 19

Streptokinase:

Question 20

Anistreplase:

Answer 20

Example of Anisoylated Plasminogen Streptokinase Activator Complex.
It is a prodrug

Question 21

They are Synthetic
Inhibit plasminogen activation

Answer 21

Aminocaproic & tranexamic acid (Hemostan)

Question 22

Stops bleeding by blocking plasmin
It can inhibit streptokinase

Answer 22

Aprotinin

Question 23

The vasopressin V2 receptor agonist
desmopressin acetate increases the
plasma concentration of von Willebrand
factor and factor VIII.

Answer 23

Desmopressin acetate