COAGULATIVE DISORDERS Flashcards
is a complex process involving
multiple steps and many clotting factors.
Hemostasis
Cutting or damaging blood vessels leads
to vascular spasm that produces a
vasoconstriction which will slow or even
stop blood flow.
Vascular phase
In larger blood vessels, platelets begin to
stick to the surfaces of endothelial cells.
Aggregation of platelets leads to the
formation of a platelet plug.
Platelet phase
The overall process involves the
formation of the insoluble protein. Fibrin
from the plasma protein
Coagulation phase
the medical term for blood clot.
Fibrin
enzyme na responsible para ma convert ang fibrinogen sa fibrin is
thrombin.
most of them are protein With the
exemption of
Clotting Factor IV – Calcium
clotting factors are synthesized from the
liver
Hemophilia B,
Christmas Factor deficiency
classic hemophilia,
Hemophilia A
thrombin activated form.
prothrombin
stationary clot
(thrombus),
A traveling clot
embolus
too much blood clot,
Thrombophilia
form within deep veins, usually in the legs
or pelvis but sometimes in the arms.
Symptoms can include swelling or pain in
the legs.
Deep Vein Thrombosis
A blood clot that forms in an artery is
called an arterial thrombosis. Arterial clots
that break apart can damage any of
several different organs.
Arterial Thrombosis
A DVT that breaks off and travels to the
lungs is called a pulmonary embolism. A
clot that becomes lodged in a lung artery
can cause lung damage, organ damage
or death.
Pulmonary Embolism
60% - 80% of patients
Def. of VWF
Type 1 VWD
15% - 30% of patients Produce VW Factor but
does NOT function the way it should
Type 2 VWD
5% - 10% of patients Total Absence of VWF
Type 3 VWD
Results after a diagnosis of an autoimmune disease,
such as lupus, or from heart disease or some
types of cancer. It can also occur after taking
certain medications
Acquired
VWD
measurement of the intrinsic power
of the blood to convert fibrinogen to
fibrin
Coagulation time test
measures how quickly your blood
clots.
Prothrombin time test
Helps evaluate a person’s ability to
appropriately form blood clots. measures the number of seconds (A normal range is
around 21 to 35 seconds.)
APTT test
Fibrinogen
Prothrombin
Tissue Factor,
Thromboplastin
IV Calcium
Factors:
I
II
III
IV
Proconvertin, Stable Factor
VIII Antihemophilic Factor
Christmas Factor
Factors:
V
VI
VII
VIII
IX
Stuart Prower Factor
Plasma Thromboplastin Antecedent
Hageman Factor
Fibrin-stabilizing Factor,
Factors:
X
XI
XII
XIII
