Bronchial Asthma - DRUGS Flashcards
SABA Short Acting Beta-2 Agonists
Salbutamol (Ventolin®)
Terbutaline (Bricanyl®)
Pirbuterol (Maxair®)
Fenoterol
LABA Long Acting Beta-2 Agonists w/ slow onset
Bambuterol (Bambec®)
It is the only beta-2-agonist administered
orally (without inhalational route)
Bambuterol (Bambec®)
LABA Long Acting Beta-2 Agonists w/ rapid onset
Formoterol
Salmeterol (Serevent®)
Salmeterol + Fluticasone
Formoterol + Budesonide
(Seretide)
(Symbicort)
Beta 2 agonist causes nervousness and
tachycardia, hypokalemic T/F
True
Bronchodilators that are reserved for
special situations
Sympathomimetic Agents
Examples of Sympathomimetic Agents
Epinephrine
Ephedrine
Isoproterenol
Drug with affinity to Alpha-1, Beta-1, Beta-2.
Epinephrine
indirect agonist, capable siya to increase the release of
catecholamines from the pre-synapse.
Ephedrine,
nonselective beta agonist. Beta-1 and Beta-2.
A potent bronchodilator
Isoproterenol
DOC for anaphylaxis
Epinephrine
Alternative controller medication
because it possesses narrow therapeutic
index
Methylxanthines
Methylxanthines cannot be used for long-term management bc mayroon siyang narrow therapeutic index. T/F
True
parent molecule of Methylxanthines
CAFFEINE
methylxanthine use for asthma
THEOPHYLLINE
bronchodilator it inhibits una. PDE 3
enzyme metabolizes cAMP and 2nd
block adenosine receptor
methylxanthine)
a synthetic analog of theophylline
less potent and shorter-acting than
theophylline
Dyphylline
Methylxanthine that does NOT
exhibit bronchodilation activity. It is not
used for asthma. used for intermittent
claudication
Pentoxifylline
1st line reliever in COPD and alternative in
BA (more useful in COPD than in asthma)
Anticholinergics
It is obtained from Datura stramonium or the Datura
metel.
Ipratropium (Atrovent)
anticholinergics with a 24-hour duration
of action. It is considered long-acting.
tiotropium
This type of anticholinergics are
quaternary ammonium compounds. So
therefore, they are poorly absorbed
orally.
Oxytropium
Prophylactic agents for asthma
stabilizes the membrane by increasing inward conduction
Mast cells Stabilizers
Mast cells Stabilizers that is poorly absorbed from the
gastrointestinal tract and must be
inhaled as a microfine powder
Cromolyn (Intal®)
has a very low bioavailability and is
available only in metered-dose
aerosol form.
Nedocromil (Tilade®)
is the least prescribed because of the
requirement of four times daily dosing
and because of occasional liver toxicity.
Zileuton (Zyflo®)
inhibits 5-lipoxygenase thereby preventing
leukotriene synthesis
5-LOX inhibitor
approved for children as young as 6
years of age. contain aspartame
Montelukast (Singulair®)
twice a day dosing (dec. patient
compliance)
Zafirlukast (Accolate®)
Montelukast chewable tablet that
contains aspartame.
Phenylketonuria
They bind to glucocorticoid
receptors on the cytoplasm of cells.
Inhibits Phospholipase A2
Corticosteroids
opposite ng Cushing-like syndrome,
Addison’s Disease.
Long acting inhaled steroids (first line controller)
B
B
F
F
Systematic oral med (short acting)
P/P
Systemic parenteral (for status asthmaticus
H
M
Example of Anti-Ige Monoclonal Antibodies
Omalizumab,
