Coagulation - mine

Question 1

poor cogaultion

• what causes
• what affects it
• signs/symps
• causes

Answer 1

acquired/ inherited

affected by meds
(heparin/warfarin)

signs/symps:
post surgical bleeding, menorrhagia, dental bleed, rectal bleed, bruising, petechiae, epistaxis

causes: low platelets, coag factor def (von will, hemophilia)

Question 2

excess coagulation

• • what causes
• what affects it
• signs/symps
• causes

Answer 2

acquired/inherited

affected by meds: estrogens

s/sx= DVT, stroke, MI, PE, arterial clot

causes: factor V Leiden mutation, malignancy, inflammation, impaired circulation

Question 3

what is hemostasis process (simplifiied

Answer 3

tissue injury
- platelets respond and tissue factor

platelet plug/fibrin clot
- platelet adhesion, activation and aggregation

fibrin degradation and clot dissolution
- plasminogen and plasmin

Question 4

thrombocytes = platelet count

-how to collect

Answer 4

collection

- venipuncture, on standard CBC

Question 5

what is the first line test related to bleeding/clotting

Answer 5

thrombocytes

Question 6

what are the indications for running a platelet count

Answer 6

screen
monitor
concern for abn bleeding/clotting

Question 7

what is a common reason for a false result of a platelet count

Answer 7

clump in lab and cause misdiagnosis

aka know you patient

Question 8

what are indications to run a PTT

Answer 8

screening for bleeding disorder

monitoring heparin

Question 9

what does factor V do

Answer 9

helps form fibrin clot, then protein c breaks it down

Question 10

what does mutated factor V leiden do

Answer 10

forms fibrin clot, resistant to break down

result is persistnet clot and thrombosis

Question 11

low vit k

Answer 11

increases PT and PTT

leads to more bleeding

Question 12

liver diseaes

Answer 12

decrease in coagulation factors= increased PT and PT and bleeding