Coagulation and Fibrinolytic QA

Question 1

1. Which of the following initiates in vivo
coagulation by activation of factor VII?
A. Protein C
B. Tissue factor
C. Plasmin activator
D. Thrombomodulin

Answer 1

B

Question 2

2. Which of the following clotting factors plays a role in clot formation in vitro, but not in vivo? in vitro clot formation and not in vivo coagulation?
A. VIIa
B. IIa
C. XIIa
D. Xa

Answer 2

C

Question 3

3. The anticoagulant of choice for most routine
   coagulation studies is:
   A. Sodium oxalate
   B. Sodium citrate
   C. Heparin
   D. Ethylenediaminetetraacetic acid (EDTA)

Answer 3

B

Question 4

4. Which ratio of anticoagulant-to-blood is correct for coagulation procedures?
A. 1:4
B. 1:5
C. 1:9
D. 1:10

Answer 4

C

Question 5

5. Which results would be expected for the
   prothrombin time (PT) and activated partial
   thromboplastin time (APTT) in a patient with
   polycythemia?
   A. Both prolonged
   B. Both shortened
   C. Normal PT, prolonged APTT
   D. Both normal

Answer 5

A

Question 6

6. What reagents are used in the PT test?
A. Thromboplastin and sodium chloride
B. Thromboplastin and potassium chloride
C. Thromboplastin and calcium
D. Actin and calcium chloride

Answer 6

c

Question 7

7. Which test would be abnormal in a patient with factor X deficiency?
A. PT only
B. APTT only
C. PT and APTT
D. Thrombin time

Answer 7

c

Question 8

8. Which clotting factor is not measured by PT  and APTT tests?
A. Factor VIII
B. Factor IX
C. Factor V
D. Factor XIII

Answer 8

D

Question 9

9. A modification of which procedure can be used to
measure fibrinogen?
A. PT
B. APTT
C. Thrombin time
D. Fibrin degradation products

Answer 9

c

Question 10

10. Which of the following characterizes vitamin K?
    A. It is required for biological activity of fibrinolysis
    B. Its activity is enhanced by heparin therapy
    C. It is required for carboxylation of glutamate residues of some coagulation factors
    D. It is made by the endothelial cells

Answer 10

c

Question 11

11. Which statement about the fibrinogen/fibrin degradation product test is correct?
    A. It detects early degradation products (X and Y)
    B. It is decreased in disseminated intravascular coagulation (DIC)
    C. It evaluates the coagulation system
    D. It detects late degradation products (D and E)

Answer 11

d

Question 12

12. Which of the following clotting factors are
measured by the APTT test?
A. II, VII, IX, X
B. VII, X, V, II, I
C. XII, XI, IX, VIII, X, V, II, I
D. XII, VII, X, V, II, I

Answer 12

C

Question 13

13. Which coagulation test(s) would be abnormal in a vitamin K–deficient patient?
A. PT only
B. PT and APTT
C. Fibrinogen level
D. Thrombin time

Answer 13

b

Question 14

15. Which of the following is referred to as an
    endogenous activator of plasminogen?
    A. Streptokinase
    B. Transamidase
    C. Tissue plasminogen activator
    D. Tissue plasminogen activator inhibitor

Answer 14

c

Question 15

16. Which protein is the primary inhibitor of the fibrinolytic system?
A. Protein C
B. Protein S
C. α2-Antiplasmin
D. α2-Macroglobulin

Answer 15

c

Question 16

17. Which of the following statements is correct regarding the D-dimer test?
A. Levels are decreased in DIC
B. Test detects polypeptides A and B
C. Test detects fragments D and E
D. Test has a negative predictive value

Answer 16

d

Question 17

18. A protein that plays a role in both coagulation and
platelet aggregation is:
A. Factor I
B. Factor VIII
C. Factor IX
D. Factor XI
Hemostasis/App

Answer 17

a

Question 18

19. A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the following morning for a
    tonsillectomy. Which of the following is the
    necessary course of action by the technologist?
    A. Run both tests in duplicate and report the average result
    B. Reject the sample and request a new sample
    C. Report the PT result
    D. Report the APTT result

Answer 18

b

Question 19

20. Which statement is correct regarding sample storage for the prothrombin time test?
    A. Stable for 24 hours if the sample is capped
    B. Stable for 24 hours if the sample is refrigerated at 4°C
    C. Stable for 4 hours if the sample is stored at 4°C
    D. Should be run within 8 hours

Answer 19

a

Question 20

21. In primary fibrinolysis, the fibrinolytic activity results in response to:
    A. Increased fibrin formation
    B. Spontaneous activation of fibrinolysis
    C. Increased fibrin monomers
    D. DIC

Answer 20

b

Question 21

22. Plasminogen deficiency is associated with:
A. Bleeding
B. Thrombosis
C. Increased fibrinolysis
D. Increased coagulation

Answer 21

b

Question 22

23. Which of the following clotting factors are
    activated by thrombin that is generated by tissue pathway (TF-VIIa)?
    A. XII, XI
    B. XII, I
    C. I, II
    D. V, VIII

Answer 22

d

Question 23

24. What substrate is used in a chromogenic factor assay?
A. p-nitroanaline
B. Chloropheonol red
C. Prussian blue
D. Ferricyanide

Answer 23

a

Question 24

25. Which of the following antibodies is used in the D-dimer assay?
    A. Polyclonal directed against X and Y fragments
    B. Polyclonal directed against D-dimer
    C. Monoclonal against D and E fragments
    D. Monoclonal against D-dimer

Answer 24

d