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gen path 2 > coagulation > Flashcards

coagulation Flashcards

1
Q

intrinsic factors consist of what

A

12, 11, 9. kallikrein

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2
Q

extrinisc

A

activation of 7 by tissue factor. also consists of 5, 10 and 2

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3
Q

Prothrombin time (PT)

A

time to form clot with thromboplastin

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4
Q

which pathway does PT measure

A

extrinsic

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5
Q

PT used in patients taking what

A

oral anticoagulants (warfarin)

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6
Q

Partial thromboplastin time (PPT)

A

time for plasma to form clot in presence of added ground glass or kaolin

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7
Q

which pathway does PPT measure

A

intrinsic

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8
Q

prolongued PT or PPT time means what

A

decreased number or abnormal factors (each one measures different factors)

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9
Q

PPT used in patients take what

A

heparin

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10
Q

bleeding time measures ____ function

A

platelet

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11
Q

prolonged bleeding time means abnormalities in what

A

platelets

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12
Q

If the mixing study corrects the clotting time, a deficiency of some _____ is felt to be present

A

factor(s)

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13
Q

If the mixing study does not correct the clotting time, an _____ is felt to be present,

A

inhibitor

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14
Q

Disorders of the _______ may be suspected if screening laboratory tests are normal.

A

regulatory system

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15
Q

mucosal bleeding is associated with ______ problem

A

platelet

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16
Q

deep tissue hematomas are associated with _____ problmes

A

coagulation factor

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17
Q

Disorders of Primary Hemostasis: clinical presentation and lab results

A

clincal- mucocutaneous bleeding

lab- prolonged bleeding time and thrombocytopenia

18
Q

Disorders of Secondary Hemostasis: clinical presentation and lab results

A

clinical- soft tissue bleeding

lab- prolonged PT and/or PTT and/or thrombin time.

19
Q

Most common inherited bleeding disorder

A

vonWillebrand diease

20
Q

The predominant clinical manifestation of vWF disease is….

A

The predominant clinical manifestation is mucocutaneous bleeding. also nosebleeds, bruises,

21
Q

what is von willebrand disease

A

abnormal funtion or number of vWF

22
Q

Because vWF is a carrier for Factor VIII, the measured level of Factor VIII also _______

A

decreases

23
Q

lab manifestations of vWF disease

A

prolonged bleeding time, prolonged PPT

24
Q

Therapeutic options for vWF disease include

A

desmopressin- releases vWF from endothelial cells

25
Q

hemophilia A is what kind of genetic disease

A

Sex-linked recessive

26
Q

hemophilia A is due to what

A

decreased production of factor Vlll

27
Q

hemophilia A clinical manifestations include

A

hemarthrosis, soft tissue bleeding, bleeding with trauma, intramuscular hematomas, intracranial hemorrhage, and generally excessive bleeding.

28
Q

only abnormal lab test in hemophilia A is what?

A

PTT time due to factor 8 depletion

29
Q

factor 8 is associated with which test

A

PTT

30
Q

Generally thrombocytopenia is present when the platelet count is < than _______

A

100,000/µL

31
Q

petechial hemorrhages in skin and mucous membranes type of bleeding is associated with what

A

thrombocytopenia

32
Q

Immune Thrombocytopenic Purpura (ITP) is simply causes

A

bleeding

33
Q

what happens in Immune thrombocytopenic purpura

A

auto antibodies made against platelets, platelets get destoryed by spleen

34
Q

acute form ITP

A
  1. children
  2. severe thrombocytopenia
  3. self limiting
35
Q

chronic ITP

A
  1. adults

2. less thormbocytopenia

36
Q

Thrombotic Thrombocytopenic Purpura (TTP): simply causes

A

clots, coagulation (platelet activation) microthrombi

37
Q

TTP is caused by a deficiency in

A

metalloproteinase, ADAMTS 13

38
Q

deficiency in metalloproteinase, ADAMTS 13

A

results in accumulation of the abnormally large vWF in the plasma.

39
Q

Disseminated Intravascular Coagulation (DIC)

A

uncontrolled activation of the hemostatic system

40
Q

Clinical situations with increased risk of occurrence of DIC include infections….

A

(Gram negative sepsis),

gen path 2 (8 decks)

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