Coag Factors ONLY Flashcards
Factor I
Fibrinogen
synthesized in liver
Not Vit K dependent
Action: form a clot
Factor II
Prothrombin
Synthesized in liver
VIT K Dependent
When active, activates I, V, VII, and XIII, PLTs and protein C
Factor III
Tissue factor or thromboplastin
Vascular wall and extravascular cell membranes
released from traumatized cells Cofactor of VII
Factor IV
Calcium
Synthesized in Diet
promotes clotting reactions
Factor V
Proaccelerin
Synthesized in liver
NOT Vit K dependent
Cofactor of X; forms a prothrombinase complex
Factor VII
Proconvertin
Synthesized in liver
VIT K DEPENDENT
Activates IX and X
Factor VIII
Antihemophiliac
Synthesized in Liver
NOT Vit K dependent
Cofactor to IX
vWF
Von Willebrand
Synthesized in Endothelial cells
mediates adhesion
Factor IX
“Christmas”
Synthesized in Liver
VIT K DEPENDENT
Activates X
Factor X
Stuart-Prower
synthesized in Liver
VIT K DEPENDENT
Activates II, forms a prothrombinase complex with V
Factor XI
Name: Plasma thromboplastin antecedent
Synthesized in Liver
Not Vit K dependent
Activates IX
Factor XII
Hageman
Liver
Not Vit K Dependent
Activates XI
Factor XIII
Fibrin Stabilizing
Liver
Not Vit K
Cross links fibrin
Made outside liver:
- Factor III Thromboplastin (vascular wall and extravascular membranes, released by traumatized cells)
- Factor IV Calcium (diet)
- vWF Von Willebrand (endothelial cells)
VIT K DEPENDENT
- Factor II Prothrombin
- Factor VII Proconvertin
- Factor IX Christmas
- Factor X Stuart-Prower
(“1972” 10, 9, 7, 2)
