Adrenergic Agonist Medications Flashcards
List drugs in the Sympathomimetic Amines class
- Epinephrine
- Norepinephrine
- Dopamine
- Isoproterenol
- Dobutamine
Direct Acting Alpha Agonists
Phenylephrine
Other Inotropes
- Vasopressin
- Milrinone
Mixed Function Agonists
•Ephedrine
Alpha 2 Agonists
•Clonidine
Beta 2 Agonists
•Albuterol
Class of Epinephrine & Route
Class: Endogenous catecholamine, adrenergic agonist
Route: IV, IM, Inhalational
Mechanism of Action of Epinephrine
Agonizes B1, B2 , A1 and A2 receptors, triggering a G protein response to increased cAMP which increases Ca, resulting in increase BP, CO , bronchial relaxation, & stabilization of mast cells
Clinical Use and Dosing of Epinephrine
Cardiac arrest, shock: 1 mg
Anaphylaxis: 100-500 mcg
Infusion: 2 – 20 mcg/min
- Low dose infusion – beta agonism predominates
- Medium dose infusion – equal beta and alpha agonism
- High dose infusions – alpha agonism predominates
Mixed with local anesthetics to decrease systemic absorption 1:200,000 (5mcg/mL of epinephrine)
Onset and DOA of Epinephrine
Onset: 1 minute
Duration: 5 – 10 minutes
Metabolism and Excretion of Epinephrine
Metabolism: MAO, COMT
Elimination: Renally excreted
Epinephrine may cause ___
tachycardia, arrythmias, angina, hypertension, decrease perfusion to splanchnic organs and uterus, and gangrene in digits
Avoid adding epinephrine to ____.
peripheral nerve blocks
Caution the use of Epinephrine in patients with ____
CAD, hyperthyroidism and pheochromocytoma
Class of Norepinephrine
Endogenous catecholamine, adrenergic agonist
Mechanism of Action of Norepinephrine
•Agonizes A1, A2 and weakly B1 receptors, triggering a G protein response to increase cAMP which increases Ca, resulting in increased BP and decreased perfusion to splanchnic organs
Clinical Use and Absorption of Norepinephrine
Clinical Use: First-line vasopressor for septic shock
Absorption: IV
Dosing, Onset and DOA of Norepinephrine
Infusion: 1 – 20 mcg/min
Onset: 1 minute
DOA: 2 – 10 minutes
Metabolism and Excretion of Norepinephrine
Metabolism: MAO, COMT
Elimination: Renally excreted
Norepinephrine may cause ____.
bradycardia (baroreceptor reflex), hypertension, profound decrease perfusion to splanchnic organs and uterus
Avoid adding norepinephrine to ___.
peripheral nerve blocks
Caution giving norepinephrine to patients with ___.
hyperthyroidism, pheochromocytoma and without central IV access d/t extravasation
Class of Isoproterenol
Synthetic catecholamine, Non-selective beta-adrenergic agonist
Mechanism of Action of Isoproterenol
Agonizes beta receptors to acts on G proteins to increase cAMP, resulting in an influx of Ca++ causing clinical effects
Clinical Use of Isoproterenol & Route
β1 effects increase heart rate, contractility, and cardiac output.
β2 stimulation causes bronchodilation and a decrease in peripheral vascular resistance and diastolic blood pressure
Route: IV
Dosing of Isoproterenol
Infusion: 0.015–0.15 mcg/kg/min
Onset and DOA of Isoproterenol
Onset: 1 minute
DOA: 1 – 5 minutes
Metabolism and Excretion of Isoproterenol
Metabolism: COMT
Elimination: Renally excreted (50% unchanged)
Isoproterenol is a poor inotropic choice in most situations because ___.
myocardial oxygen demand increases while oxygen supply falls
Caution use of Isoproterenol in patients with what conditions?
CAD, hypertrophic cardiomyopathy, hyperthyroidism, pheochromocytoma
Class of Dopamine
endogenous nonselective adrenergic and dopaminergic agonist, direct and indirect acting
Mechanism of Action of Dopamine & Route
dopamine stimulates D receptors, β-receptors, and α-receptors in a dose-dependent manner because of differing receptor affinities.
Route: IV
Renal Dosing of Dopamine
Not scientifically supported (urine output increases, but long-term morbidity and mortality do not improve)
Dosing of Dopamine
Dopaminergic receptors: 2 mcg/kg/min
β receptors: 2 to 5 mcg/kg/min
α receptors: greater than 10 mcg/kg/min