CNS protozoa Flashcards
HIV pt w/ brain abscess (ring enhancing lesion)
chorioretinitis, hydrocephalus, intracranial calcifications
Toxoplasma gondii
classic triad of toxoplamosis
Tgondii transmission
cysts in meat or cat feces
can also cross placenta
Tgondii Dx
serology, biopsy
Tgondii Tx
Sulfadiazine+pyrimethamine
meningoencephalitis (rapidly deadly)
Naegleria fowleri
N fowleri transmission
swimming in freshwater lakes; enters via cribriform plate
Carry FRESH waster in NALGENE bottle (freshwater, naegleria)
Naegleria fowleri Dx
amoebas in spinal fluid
Naegleria fowleri Tx
Amphotericin (for some)
enlarged lymph nodes, recurring fever, somnolence, coma
African sleeping sickness
Trypanosoma (brucei, gambiense, rhodesiense; NOT CRUZI)
Why is fever w/trypanosomes recurring?
Antigenic variation
Trypanosome brucei/gambiense/rhodesiense transmission
Tsetse fly
painful bite (vs painless bite with Trypanosoma cruzi)
Tbrucei/gambiense/rhodesiense Dx
blood smear
T(not cruzi) Tx
SURamin for bloodborne disease
MELArsopol for CNS penetration
it SURe is nice to sleep. MELAtonin helps with sleep.
