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Path Unit 3 > CNS Neoplasias > Flashcards

CNS Neoplasias Flashcards

1
Q

Whorled Pattern Psamoma Bodies Most common CNS tumor Not invasive

A

Meningioma

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2
Q

most common type of malignancy of CNS

A

metastatic

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3
Q

Ring Enhancing lesion central necrosis with psueodpallasading tumor cells “butterfly” on CT malignant astroglial cells

A

Glioblastoma multiforme

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4
Q

Rosenthal fibers (arrow)

Non-invasive

child/young adult

A

Pilocytic Astrocytoma

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5
Q

Fried egg and chicken wire appearance

age 40-50

t(1:19) is a good prognosis

A

Oligodendrogiomas

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6
Q

Perivascular Pseudorosette

GFAP+

Mass usually in 4th ventricle

May cause hydrocephalus

(DDX: Choroid plexus papilloma-NOT GFAP+)

A

Ependymoma

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7
Q

Midline vermis in children

Cerebellar Hemispheres in Adults

Nausea, vomitting and ataxia

small hyperchromic cells

rare neuroblastic rosettes

A

Medulloblastoma

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8
Q

Inactivation of INI-1 (tumor supressos)

mixed cell type

May present with tumors in kidney in predisposition syndrome

A

Rhabdoid tumor

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9
Q

Derived from Rathke Cleft remnants

In Sella Turcica region

Present with endocrine and visual disturbances

Mainly in children

A

Craniopharyngioma

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10
Q

Ddx for CNS tumor with visual disturbances

A

Pilocytic astrocytomas (Rosenthal Fibers)

Pituitary Adenoma

Craniopharyngioma

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11
Q

Arise in midline structures

OCT3/4, c-kit, and placental alk phos +

might be b-HCG +

Better prognosis with single germ layer

A

Germ Cell tumors (germimoma, teratoma, choriocarcinoma)

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12
Q

Cerebellum

Cyst with enhancing mural nodule

Might secrete EPO causing polycythemia

A

Hemangioblastoma

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13
Q

Most common tumor associated with temporal lobe epilepsy

A

Ganglioglioma

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14
Q

Originates deep in hemispheres (usually periventricular)

more common in immunosupressed and AIDS

A

Primary CNS Lymphoma

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15
Q

Hemangioblastoma+ retinal angiomas

A

von Hippel–Lindau Disease

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16
Q

Hamartomas of brain, retina and viscera

Subependymal giant cell astrocytomas-“candle dripping”

A

Tuberous Sclerosis

17
Q

Angiomas of brian and face

unilateral “port wine stain”

nevus flammeus

A

Sturge-Weber Syndrome

18
Q

Benign, slow growing encapsulated neoplasm of schwann cells from vestibular branch of CN8

sensorineural hearing loss

tinnitus

vestibular dysfunction

A

Vestibular schwannoma

(NF2 gene–>bilateral vestibular schwannomas)

19
Q

Benign, slow growing encapsulated neoplasm of schwann cells from dorsal spinal roots

radicular pain

spinal cord compression

schwann cells grow into nerve

A

Spinal and peripheral Schwannoma’s

Path Unit 3 (8 decks)

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