CNS Infections Flashcards

1
Q

Inflammed btwn pia and arachnoid meninges
Neck Rigidity
Kernigs Sign
Brudzinki Sign

A

Leptomeningitis

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2
Q

Low glucose in CSF
fever
neck rigidity

A

bacterial meningitis

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3
Q

newborn meningitis

A

E Coli (or Group B Strep)

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4
Q

Meningitis from 3 months-3 years old

A

H INfluenzae

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5
Q
  • Main cause of meningitis later in life
  • Might have hx of basilar skull fx
  • Alcoholics and asplenics
A

strep pneumo

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6
Q
  • Contracted in congested places (schools and barracks)

- Waterhouse Friderichsen Syndrome

A

N. Meningitides

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7
Q
  • Cerebritis
  • Astrogliosis
  • Encapsulated by fibroblasts
  • Can rupture into ventricles
A

cerebral abscess

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8
Q
  • Increased CSF Protein
  • Obliterative endarteritis
  • Can induce cortex or brainstem infarcts
A

Neurosyphilis

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9
Q
  • Loss of joint position sense and fine touch (dorsal column)
  • Positive Romberg Sign
A

Tabes Dorsalis

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10
Q

Sluggish replication of T. pallidum spriochetes

  • “Wind Blown appearance” of residual nerve cells
  • gliosis
A

Leutic Dementia

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11
Q
  • granulomatous response with giant cells and lymphocytes
  • surrounds areas of caseous necrosis
  • Commonly localized to base of brain
A

Tuberculous Meningitis

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12
Q

Tuberculosis of the spine

A

Pott Disease

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13
Q
  • Oppurtunistic infection
  • Soap Bubble abscesses
  • Encapsulated fungi in Virchow Spaces
  • India Ink shows clear halo
A

Cryptococcus meningitis

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14
Q

Name 6 other fungal causes of meningitis aside from cryptococcus (most common)

A
Coccidiomycosis-san joaquin valley
Histoplasmosis-mississippi
Blastomycosis
Mucormycosis
Aspergillosis
Candidiasis-microabscesses
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15
Q
  • Usually a benign meningitis
  • Sudden febrile illness with headache
  • Excess lymphocytes in CSF
  • Increase in protein
  • No change in glucose
A

Viral meningitis

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16
Q
  • Inflammation of grey matter in spinal cord
  • fever, malaise and headache
  • develops into meningitis and paralysis
A

poliomyelitis

17
Q
  • Enters CNS thorugh retrograde axoplasmic flow
  • Negri Bodies-eosinophilic cytoplasmic viral inclusion bodies
  • Hydrophobia-difficulty swallowing
  • Death without vaccine and Ig
A

Rabies

18
Q
  • Cowdry A intranuclear eopsinophilic inclusions surrounded by halo
  • Commonly localizes to temporal region
A

HSV1 meningitis

19
Q
  • Crosses placenta and induces encephalitis in utero
  • Periventricular necrosis and calcification –>obstructive hydrocephalus
  • Eosinophilic viral inclusions
A

CMV

20
Q
  • JC Virus infects oligodendrocytes–>cytolysis and demyelination
  • discrete foci of demyelination near grey-white junction
A

Progressive Multifocal Leukoencephalopathy

21
Q

In and HIV+ patient, name the most common:

1) fungal meningitis
2) intracranial mass
3) neoplasma

A

1) Cryptococcus
2) toxoplasmosis
3) Primary CNS lymphoma