CNS Cognitive Questions Flashcards
40 yr old non-vegetarian man presented to the ER with headache, vomiting & recurrent epileptic seizures. MRI showed multiple ring enhancing lesions with edema in his brain.
a. What is the probable clinical diagnosis?
b. What is the organism implicated?
c. What is the mode of transmission of this disease?
d. What is the larval stage of this condition?
a. Neurocyticercosis
b. Taenia Solium
c. Feco-oral route, Contaminated food and waste
d. cysticercosis cellulosae
You have made a clinical diagnosis of meningitis in a 50-year-old HIV infected immunocompromised woman. A latex agglutination test on the spinal fluid for capsular polysaccharide antigen is positive.
a. Which one is the MOST likely cause?
b. What is the special stain used to visualize the capsule?
c. What is the mode of transmission of this disease?
d. Name one culture media for the growth of this pathogen?
a. Cryptococcus
b. Negative staining / India ink
c. Inhalation
d. Bird seed agar
A 35-year-old man admitted in the emergency room with complaints of severe headache,
vomiting, seizure and fever (40°C) that began last night. He is “foaming at the mouth”
and cannot drink any liquids. He dies after two days. Pathologic examination of the brain
reveals eosinophilic inclusion bodies in the cytoplasm of neurons.
a. The most likely diagnosis is?
b. Name the inclusion body found in the neurons.
c. What is the genome of this pathological agent?
d. Which is the gold standard method in diagnosis of this condition?
a. Rabies
b. Negri
c. ssRNA
d. Antigent detection (by Direct IF)
A 25 yr old boy is presented with deep injury and abrasions on the left shoulder, thigh and leg following a RTA. He developed muscle stiffness pain, trismus and opisthotonus position. His immunization status unknown excised tissue bits from necrotic depths of the
wound revealed gram positive bacilli.
a. What is the probable causative agent?
b. What type of spore is produced by this organism?
c. Which toxin is responsible for this condition?
d. What is the next line of management for this condition?
a. Tetanus
b. Clostridium tetani
c. Tetanospasmin
d. Immunoglobulins are given & TT
A 58 year old HIV infected female presented with altered mental status, seizures, and sensory abnormalities. The bone marrow aspirate collected was sent for giemsa stain which revealed crescent shaped tachyzoites.
a. What is the causative agent?
b. Which is the definitive host?
c. What are the morphological forms of this condition?
d. What is the drug of choice?
a. Toxoplasma gondii
b. Cat
c. Tachyzoite (crescent shaped), Bradyzoite, (Unsporulated and sporulated) Oocyst, Cyst
d. In immunocompotent patients with lymphadenopathy do not require any treatment. But immunocompromised need: DOC - Cotrimoxazome
Dapsone-Pyrimetamine
