CNS Flashcards
What do These cause
Threshold stimulus
Subnthreshold stimulus
Supra threshold stimulus
Action potential
Local potential
Increased frequency of action potential
What is adequate stimulus
It is the stimulus to which receptor is most sensitive or to which receptor responds at low energy levels
What is a receptor
A biological transducer (converts one form of energy into another form of energy
What do receptors code for (4)
- site/location
- modality
- intensity
- duration
What is adaptation
Stimulus is present but response of receptor decreased over time
Rapidly adapting receptor features
Phasic
Encapsulated nerve
Can detect rate of change of stimulus
Slowly adapting receptor features
Tonic
Expanded of brain nerve endings
Can detect a steady stimulus
Types of phasic receptors
Pacinian corpuscles
Meissners corpuscles
Hair end organs
Tonic receptors
Merkel’s disc Ruffini’s endings C-mechanoreceptors Receptors for position sense-joint capsule,muscle spindle,golfi tendon organs Thermoreceptors
Cold thermoreceptor fibre
Adelta and C
Cold thermoreceptors detect range of temperature
40 degree Celsius to 10 degree Celsius
Below 10 degree no activation of thermoreceptors
Activation of nociceptors
Cold thermoreceptors detect range of temperature
Can detect temperature up to 45 degree Celsius
After 45 degree stimulation of nociceptors
Types of nociceptors
Mechanical
Chemical
Thermal
Polymodal
Ascending sensory tracts
Posterior column
Spinothalamic tract
Spinocerebellar tract
Posterior column sensation
Conscious proprioception Fine touch localisation Two point discrimination Vibration Stereognosis Ability to judge different degrees of pressure
Spinothalamic tract sensation
Lateral – pain, temperature
Anterior – crude touch, itching, tickle, sexual sensation, detection of pressure
Spinocerebellar tract sensation
Unconscious proprioception
Tracts from lower limb and upper limb in spinocerebellar
Lower limb-
Dorsal/posterior/ fleschig’s (m. Spindle,GTO) uncrossed
Ventral/anterior/gower’s tract(GTO) crossed
Upper limb
Cuneocerebellar
Rostral spinocerebellar
(Similar to above)
Posterior column diagram
See it
Sensory homunculus sensitive areas
More sensitive areas have larger cortical representation
Eg face lips hand fingers
Spinothalamic tract diagram
See it
Spinal tumours type and sensation loss
Medullary and extra-medullary
Descending sensory loss and ascending sensory loss resp
Fast pain fibres and their stimulus
Adelta
Mechanical/thermal
Neurotransmitter of fast pain
Glutamate
Fast pain fibres synapse in
Either lamina 1 or 5
Slow pain fibres and their stimulus
C fibres
Chemical
Neurotransmitter of slow pain
Substance P
Slow pain fibres synapse in
Lamina 2 aka substantia gelatinosa of rolambo
Collateral given by C fibres
Reticular formation
Periaqueductal
Peri ventricular
Name the endogenous analgesia systems
Gate control theory of melzac and wall
Defending pain inhibiting pathway
(Also know the diagrams)
TENS full form and based on ?
Transcutaneous electrical nerve stimulation
Based on gate control theory
Symptoms of neuropathic pain
Allodynia
Hyper Algeria and give eg
What is Bell Magendie law
dorsal/posterior horn of spinal cord supply sensory
Ventral anterior horn of spinal cord supplies motor
What is the law of projection
If nerve is stimulated anywhere in its course sensation appears to be arising from its site of receptor
Eg.phantom limb
What is the mean theory behind phantom limb
Cortical plasticity
Cortex (and even thalamus) have ability to form new synapses
Other theory – law of projection
What are the laws for intensity discrimination of stimulus
Weber feschner law -sensation=KlogI
Stevens power laws KI^a
Specific sensory relay nuclei present for somatic sensation
Ventero postero-lateral nucleus/ventero-Basal complex
Specific sensory relay nuclei present for vision
Lateral Geniculate body
Specific sensory relay nuclei present for hearing
Medial geniculate body
Specific sensory relay nuclei present for taste
Ventero-postero-medial
Specific sensory relay nuclei present for olfaction
Dorsomedial/mediodorsal thalamic
Motor nucleus of thalamus
Ventro lateral
Ventro anterior
Papez circuit controls what
Memory
Emotion
Learning
Do you know them papez circuit
Please check your notes
Lateral descending tracts
Supplies?
Lateral corticospinal tract (pyramidal tract)
Rubrospinal tract
AAlpha especially flexors of upper limb
Medial descending tracts
Supplies?
Anterior corticospinal
Tecto spinal tract
Vestibulo-spinal tract
Aalpha esp extensors of lower limb
Reticulo-spinal tract
Agamma esp ext LL
Reticulo-spinal tract two types
Pontine/excitatory
Medullary/inhibitory
Corticospinal tract origins
Primary motor cortex(area 4) – 30%
Promoter and supplementary motor cortex (area 6)– 30%
Sensory cortex (3,1,2)– 40%
Fibres arising from internal capsule
Anterior to 2/3rd of posterior limb – corticospinal
Genu– cortico bulbar
What is known as the window of limbic system
Amygdala
Anterior corticospinal and lateral corticospinal
Which supplies both sides
Anterior corticospinal supplies both sides
Lateral corticospinal only supplies the opposite side
What happens if there is a thromboembolic/haemorrhagic lesions of middle cerebral artery (lenticular artery)
Dense hemiplegia of opposite side
Brown sequard syndrome
Hemisection of spinal cord
Features of brown sequard
Temp,pain opposite side lost All other sensations lost on same side Motor paralysis of same side BULL- Below level of lesion UMN at Level of lesion LMN
Parts of cerebellum
Vestibule-cerebellum
Neo-cerebellum
Spinocerebellum
4 pairs of nuclei of cerebellum
Fastigeal
Globose
Emboliformis
Dentate
Largest nucleus of cerebellum
Dentate nucleus
5 cells of cerebellum
Stellate Basket Purkinje Granule Golgi
Granule is excitatory
Rest inhibitory
Output from cerebellum and cerebellar cortex
Deep nuclei and purkinje cells resp
Input fibres of cerebellum
Climbing fibres
Mossy fibres
What are the climbing fibres formed by
Olivocerebellar tract
Vestibulo-cerebellum function
Balance
Eye movements
Neo-cerebellum function
Motor planning
Functions of spinocerebellar
Motor coordination
Diagram of cerebellar cortex
With cells nuclei et cetera
Inhibition types seen in cerebellum
Feed forward
Feedback inhibition
Basal ganglia functions
Motor planning
Coordination of automatic and associated movements
Parts of the basal ganglia
Caudate nucleus
Putamen
Globus pallidus – external segment and internal segment
Substantia nigra – pars reticularis, pars compacts
Sub thalamic nucleus of lewy’s
Receptors present in the parts of basal ganglia
GABA in all parts except
Pars compacta – dopamine
Subthalamic nucleus of Lewy’s- glutamate
Postural reflex types
Spinal
Medullary
Midbrain
Cortical
Types of spinal reflexes
Stretch reflex
Inverse stretch reflex
Positive supporting reaction/magnet reaction
Negative supporting reaction
What are the two things that cause stimulation of muscle spindle - Muscle contraction
Increase in muscle length
A gamma motor nerve discharge
What is efferent/motor to muscle spindle
a gamma
Efferent arm of stretch reflex
A alpha
Stimulus for stretch reflex and inverse stretch reflex
Stretch reflex – increase in muscle length
Inverse stretch reflex – increase in muscles tension
No the diagrams of both please please I beg you
Medullary reflexes
Tonic neck reflex
Labyrinthine/vestibular reflex
Mid brain reflexes
All righting reflexes
Cortical reflexes
Hopping
Placement
Jendrassik’s manoeuvre
Example – hooking of fingers, clenching of teeth
It increases Agamma motor nerve discharge
Increases muscle spindle sensitivity
Functions of hypothalamus
TEN HARTS Temperature regulation Endocrine Neuro endocrine Hunger Centre ANS Rage Centre, Reward centre Thirst Centre Satiety centre, sexual
If lateral hypothalamus of experimental animal is stimulated what happens
Animal is hungry thirsty violent and aggressive
What controls temperature regulation in the hypothalamus
Posterior hypothalamus – heat loss Centre
Anterior hypothalamus – heat loss Centre
What are the different mechanisms response to cold
Peripheral Vasu construction
Non-shiveringthermogenesis
Shivering
Heat loss mechanism
Peripheral vasodilation
Sweating
Supra optic and para ventricular nucleus secrete what predominantly
Supra optic – 5/6 ADH, 1/6oxytocin
Para ventricular – 1/6 ADH, 5/6 Oxytocin
Mnemonic – Om Prakash
know the endocrine and neuro endocrine functions of the hypothalamus
Just know it
Look at your notes please
Accidental transection of pituitary stock will increase which hormone
Prolactin
Volume of CSF
150 ML
Daily production of CSF
550 ML (0.38ML/minute)
CSF secreted and absorbed by
Secreted by choroid plexus
Absorbed by arachnoid villi
What is dependent on CSF pressure
CSF secretion or CSF absorption
CSF absorption
What happens to the absorption when CSF pressure is
More than 112 mm water
Less than 112 mm water
Less than 68 mm water
Increase CSF absorption
Decrease CSF absorption
Absorption stops
What are circumventicular organs
No blood brain barrier
Fenestrated capillaries
Examples of circumvetricular organs
OVLT – organum vasculosum of lamina terminalis SFO– subfornicial organ Area postrema Median eminence Posterior pituitary
EEG invented by
Hans Berger
Know what each of the waves of EEG does
Check notes
Which is called paradoxical sleep
REM
Neurotransmitters during awake time
Increased norepinephrine
Increase serotonin
Decreased as acetylcholine
Decreased GABA
Increased histamine
During NREM and REM – opposite of above
Types of long-term memory
Declarative/explicit
Non-declarative/implicit
Types of declarative memory
Semantic
Episodic
Types of non-declarative memory
Procedural
Priming and Perceptual
Associative learning
Non-associated learning