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Physiology > Cell Membrane And Transport > Flashcards

Cell Membrane And Transport Flashcards

1
Q

Ficks law of diffusion

A

J=-DA delta c/delta x

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2
Q

Most important factor determining movement of lipid soluble substance across cell membrane

A

Lipid solubility >molecular diameter>molecular weight

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3
Q

Nephron transporters

A 
UTA1
UTA2
.
.
UTA4
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4
Q

RBC and vasa recta transporter

A

UTB

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5
Q

Non-ionic diffusion of NH3 where

A

Collecting duct

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6
Q

Eg of non-ionic diffusion

A

Secretion of NH3 by collecting duct cells
Excretion by weak acids and weak bases by collecting duct
Absorption of weak acids by stomach
Absorption of bile acids by distal ileum

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7
Q

Primary active transport by

A

Na-k pump
H-k pump
SERCA

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8
Q

Secondary active transport types

A

Co-transport

Counter transport

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9
Q

Main function of Na-k pump

A

Genesis of RMP

Cell volume regulation

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10
Q

Binding site on Na-k pump on ECF side

A

K- binding site

Ouabain binding site

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11
Q

3 sites on inner side of Na-k pump

A

Na binding site
ATP binding site
Phosphorylation site

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12
Q

Affect of hormones on Na-k pump

Thyroid,aldosterone,insulin,dopamine,anp

A

Check book ;)

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13
Q

Co transport counter transport eg

A

Check notebook pls 🤲🏽

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14
Q

Eg of docking protein

A

Syntaxin/T-snare protein
Synaptobrevin/V-snare protein
SNAP-25

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15
Q

Eg of non-constitutive/regulated exocytosis

A

Synthesis-processing-storage-release

Eg pls check

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16
Q

Constitutive pathway exocytosis eg

A

Synthesis-release
Secretion of Ig by plasma cell
Secretion of collagen by fibroblast

17
Q

Pinocytosis eg

A

Ca
ATP
Cadherin
Caveolin

18
Q

Transcytosis eg

A

Colostrum to baby blood

(As intestinal epithelium is not mature in newborn

19
Q

Donnan effect

A

When two compartments are separated by semipermeable membrane with impermeant anions (protein-) on one side of this semi-permeable membrane,there is an unequal distribution of a pair of diffusable ions at equilibrium (no net transport)

20
Q

Gibbs-donnan equation

A

Gives the mathematical relationship between 2 diffusible ions at equilibrium in 2 compartments separated by semi-permeable membrane with impermeant anions (-pr) on one side of this semipermeable membrane

21
Q

Nernst equation

A

To calculate equilibrium potential

Equilibrium potential=2.3 RT/FZ log c1/c2
(Know what each of those letters mean)

2.3RT/F =61.5 mV (approx 60 mV)

22
Q 
Equilibrium potential of 
K
Cl
Mg
Na
Ca
A 
K=-90mv
Cl=-70mv
Mg=0mv
Na=+61 mV
Ca=+125 mv
23
Q

Resting membrane potential given by which equation

A

Goldman Hodgkin Katz equation

24
Q

Goldman Hodgkin Katz equation based on 2

A

Conc gradient of ions

Cell membrane permeability for the ions

25
Q

Check the equation pls

So in the equation conc for negative charge ion on the numerator side is of outside or inside

A

For negative ion the outside conc is numerator

26
Q

Cell membrane is most permeable to which ion at rest

A

K+

27
Q

Most diffusible ion at rest

A

K+

28
Q

If extracellular concentration of Na+ is increased agar happens to RMP

A

No Change (Membrane is almost impermeable to Na)

29
Q

Which ion contribute to maximum to RMP

A

K+

30
Q

Values of RMP of different cells

A

Pls pls check your mobile

31
Q

Effect of hypokalemia on RMP and common symptom

A

Increase potential
Decreased excitability
Symptom -muscle weakness

If you don’t know how it happens pls go through your notes -.-

32
Q

Effect of hyperkalemia on RMP and common symptom

A

Increase potential
Decrease excitability
Symptom-arrhythmia

If you don’t know how it happens pls go through your notes -.-

33
Q

Two types of channels

A

Leak

Gated

34
Q

Types of gated channels

A

Voltage gated
Ligand gated
Phosphorylation channel
Mechanosensitive

35
Q

Dimer trimer tetramer pentamer channels

A

Dimer -not in humans (chloride channels in bacteria,animals)
Trimer - ENaCs (epithelial Na channel)
Tetramer - K+,acquaporin
Pentamer- chloride channel,ligand gated channel (acetylcholine receptor)

36
Q

Feedback systems

A

Negative
Positive
Adaptive control

37
Q

Negative feedback eg

A

Control of blood pressure with baroreceptor mechanism

38
Q

Positive feedback eg (mnemonic)

A 
C-clotting,ca release from SR during muscle contraction 
L- LH surge,let down reflex 
A-action potential 
P-parturition 
S-shock
39
Q

Gain of negative feedback system formula

A

Correction/error

Physiology (7 decks)

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