CNS Flashcards
1
Q
what kind of system is GABA
A
inhibitory
2
Q
what does GABA bind to?
A
GABAa receptors on Cl- ion channels
3
Q
what does GABA binding cause?
A
Cl- ion influx and hyperpolarisation
4
Q
effect of ethanol on the GABA system
A
allosteric modulator to GABA causing a greater influx of Cl-
5
Q
effect of tolerance on the Cl- channels
A
internalise to reduce amount of Cl- in-fluxing
6
Q
what is the effect of the tolerance once ethanol is removed?
A
reduced Cl- so reduced hyperpolarisation leading to more APs and an over-activated NS
(greater susceptibility to seizures)
7
Q
management of tolerance
A
benzodiazepines
8
Q
what enhances dopamine release?
A
ethanol
9
Q
what does dopamine bind to?
A
GABA receptors
10
Q
pathway for dopamine release?
A
mesocorticolimbic pathway
