Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

H/O RC > CML > Flashcards

CML Flashcards

1
Q

Ph chromosome breakpoints

A

t(9;22) - Philadelphia

p190 - more ALL
p210 - more CML

(alphabetical)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CML major molecular response

A

<0.1% BCR-ABL or >3 log reduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CML phases

A

Chronic phase
Accelerated phase: blast 10-30%
Blast phase: blast >30%; 1/3 AML, 2/3 ALL –> HSCT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CML TKI options

A

Imatinib
Dasatinib - faster/deeper remission
NIlotinib - faster/deeper remission
Ponatinib (for T315I mutation or TKI resistance)

all have similar OS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

TKI s/e

A

myelosuppression
fluid retention
rash
hepatotoxicity (transaminases)
endocrinopathies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CML HSCT criteria

A

accelerated/blast phase
failure of multiple TKI
unacceptable/intolerable TKI toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

H/O RC (31 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions