Clotting Disorders Flashcards
What is Factor V Leiden?
Activated Protein C Resistance
Most common inherited thrombophilia
What is the inheritance of Factor V Leiden?
Risk of thrombosis increases if homozygous
What is the management of Factor V Leiden?
No specific management
What is post-thrombotic syndrome?
Venous outflow obstruction and venous insufficiency results in chronic venous hypertension
How does post-thrombotic syndrome present?
Painful heavy calves
Pruritus
Swelling
Varicose Veins
How is Post-Thrombotic Syndrome managed?
Graduated compression stockings and leg elevation
What is Thrombocytosis?
Platelet count over 400
Give four causes of thrombocytosis
Reactive
Malignancy
Hyposplenism
Essential Thrombocytosis
What is essential thrombocytosis?
Myeloproliferative disorder with a platelet count >600
How does essential thrombocytosis present?
Thrombosis and bleeding seen
Burning sensation in hands
How is essential thrombocytosis managed?
Hydroxycarbamide (or interferon alpha)
Low dose aspirin
What is Antiphospholipid syndrome?
Predisposition to arterial and venous thrombosis
Can be primary or secondary
What are the risks of Antiphospholipid syndrome in pregnancy?
Recurrent loss
IUGR
Placental abruption
How is Antiphospholipid syndrome managed?
Low dose aspirin from positive pregnancy test
LMWH from HB noticed until 34 weeks
