Bleeding Disorders Flashcards
What is characteristic of prolonged APTT only?
Haemophilias
What is characteristic of prolonged APTT and bleeding time?
VWD
What is characteristic of Prolonged APTT and PT?
Vit K deficiency
What is DIC?
Inappropriate systemic activation of clotting cascade resulting in bleeding
Mediated by tissue factor
What results are characteristic of DIC?
Prolonged everything
Low Platelets
Give three causes of DIC
Sepsis
MAlignancy
Amniotic FLuid Embolism
Name three ways Haemophilias can present
Haematomas
Haemarthroses
Prolonged Bleeding
What is the problem with Haemophilia A treatment?
Patients can form an immune response against Factor VIII treatment - resistant
What is the difference between ITP in Children and Adults?
Children - normally acute and post infection/vaccine
Adults - Chronic
How does ITP present?
May be incidental finding on blood films
Petichiae
Purpura
Epistaxis
How is ITP investigated?
Bloods - Isolated Thrombocytopenia, and raised antiplatelet IgG
Blood Film
BM Biopsy (to rule out leukaemia)
How it ITP managed?
Prednisolone
Pooled IVIG if actively bleeding/pre op
What is TTP?
Deficiency in enzyme that normally cleaves multimers of VWF
Caused by pregnancy/SLE/HIV etc
How does TTP present?
Fever
Fluctuating neurological signs
Renal Failure
How does TTP present on blood tests?
Thrombocytopenia and MHA
