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Clin Med 1 Test 3 > Clostridia > Flashcards

Clostridia Flashcards

1
Q

what is the classification of Clostridial species

A

GP spore-forming rod, anaerobes

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2
Q

where are Clostridial spp’s found (3)

A

soil, aquatic sediment, GI of animals

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3
Q

the 4 Clostridial spp’s of CONCERN

A

perfringens, difficile, tetani, botulinum

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4
Q

in what illnesses is C. perfringens the culprit (3)

A

food poisoning, surgical inf, gas gangrene

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5
Q

what is Clostridial Myonecrosis

A

gas gangrene

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6
Q

MC predis[osing condition to C. Perfringens inf

A

injection drug use

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7
Q

how does gas gangrene appear (3 features)

A

pale to colorful skin, swelling with possible subQ emphysema, brown malodorous discharge

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8
Q

3 necessary steps to gas gangrene tx

A

surgical debridement, PCN q3hrs IV, HBO2

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9
Q

what is deadly about C tetani

A

it produces neurotoxin tetanospasmin leading to airway obstruction

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10
Q

how long after infection before signs of tetanus appear

A

5days to 15 WEEKS (avg ~10 days)

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11
Q

name of rigidity in mm’s of back, neck, ABD

A

Opisthotonis

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12
Q

Ddx for tetanus (3)

A

meningitis, tranquilizer use (phenothiazine, thorazine), rat poisoning (strychnine, compazine)

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13
Q

3 necessary steps to tetanus tx

A

sedation, ventalation, human tetanus globulin (TIG) administration

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14
Q

MCC botulism

A

home-canned foods (smoked meats, vac-packed fish)

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15
Q

why do infants get botulism

A

sensitive to the small amt of C. botulinum in honey

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16
Q

what is the caue of wound assoc botulism

A

drug injection

17
Q

what is the course of the dz of botulism

A

diplopia, ptosis, CN palsies, paralysis (resp failure)

18
Q

Ddx for botulism (3)

A

myasthenia gravis, Gillian Barre Syndrome (C Miller Fisher variant), Vertebrobasilar insufficiency

19
Q

3 necessary steps to botulism tx

A

get antitoxin from CDC, ventilate, IV fluids

Clin Med 1 Test 3 (16 decks)

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