Clopidogrel Flashcards
1
Q
Clopidogrel uses • ACS • Coronary artery stenting • Hypertension • Acute ischaemic stroke • AF • Myocardial perfusion scan • Cardio, cerebo peripheral arterial disease
A
Clopidogrel uses • ACS • Coronary artery stenting • AF • Cardio, cerebo peripheral arterial disease
2
Q
Clopidogrel MOA • Increases cAMP • Block adenosine • Irreversibly inhibits COX • Prevent platelet aggregation • Decrease platelet aggregation • Irreversible binding to ADP
A
- Prevent platelet aggregation
* Irreversible binding to ADP
3
Q
SE of clopidogrel • Bleeding • GI upset • GI ulcer/ haemorrhage/ disturbance • Headache, flushing dizziness • Tinnitus • Bronchospasm • Thrombocytopaenia
A
- Bleeding
- GI upset
- Thrombocytopaenia
4
Q
Warning with Clopidogrel • Active bleeding • 3rd trimester of pregnancy • Child <16 • Aortic stenosis • Elective surgery • Gout • Peptic ulceration • Renal impairment
A
- Active bleeding
- Elective surgery
- Renal impairment
5
Q
Interactions • Anticoagulants • Erythromycin • Antiplatelets • Adenosine • CCB • Cytochrome p450
A
- Anticoagulants
- Erythromycin
- Cytochrome p450
