CLL--Krafts

Question 1

BM transplants in lymphoproliferative disease

Answer 1

not an option malignancy remains in lymph nodes

Question 2

CLL odd immunophenotype

Answer 2

B-cell, but CD5+

(usually in T-cells and immature B-cells)

Question 3

CLL cells

Answer 3

small, mature lymphocytes

Question 4

CLL prognostic tool

Answer 4

BM section

(diffuse involvement –> worse)

Question 5

Immunophenotype of CLL

Answer 5

+ B-cell antigens

+ CD5

• TdT

Question 6

2 lab findings in CLL

Answer 6

high WBC

hypogammaglobulinemia

Question 7

Gene rearrangement of CLL

(commonly)

Answer 7

bcl-2

(normally prevents apoptosis–cells become “immortal”)

Question 8

Hairy Cell Leukemia

physical exam finding

Answer 8

splenomegaly without lymphadenopathy

Question 9

Hair Cell Leukemia

Blood Findings

Answer 9

pancytopenia

Question 10

Hair Cell Leukemia

Stain

Answer 10

TRAP +

Question 11

Hairy Cell Leukemia

men or women?

Answer 11

5: 1
men: women

Question 12

Answer 12

Hairy cell leukemia

TRAP stain

Question 13

Why don’t you get hairy cells out in peripheral blood in hair cell leukemia?

Answer 13

hairy cells make reticular fibers around themselves in the BM

Question 14

Why do you get a pancytopenia in Hair Cell Leukemia?

Answer 14

reticular fibers made around hairy cells, makes it harder to get out of marrow

Question 15

Immunophenotype for hairy cell leukemia

Answer 15

+ CD25, CD11c

Question 16

Always peripheral blood finding in hairy cell leukemia

Answer 16

monocytopenia

Question 17

Prolymphotyic Leukemia

physical exam findings

Answer 17

splenomegaly without lymphadenopathy

Question 18

Special about prolymphocytic leukemia

Answer 18

aggressive

splenomegaly without lymphadenopathy

nucleoli present

Question 19

Large Granulated Lymphocyte Leukemia

Cells

Answer 19

T-cell proliferation with neutropenia

Question 20

Answer 20

prolymphocytic leukemia

look at the nucleolus!