Antiangiogenesis Drugs--Fitz Flashcards

1
Q

Bevacizumab

A

MOA: humanized monoclonal antibody against VEGF

TU: metastatic colorectal cancer w/ 5-FU, lung cancer, macular degeneration

Tox: GI performation*, wound dehiscence, hemoptysis, worsen coronary artery disease

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2
Q

Sorafinib

A

MOA: VEGF and PDGF TK antagonists

TU: renal cell carcinoma

PK: CYP3A4 metabolism

Tox: CHF, MI, teratogenic, HTN, hemorrhage

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3
Q

Pazopanib

A

MOA: VEGF and PDGF TK antagonist

TU: renal cell carcinoma

PK: CYP3A4 metabolism, high plasma protein binding, PO

Tox: CHF, MI, teratogenic, hepatotoxicity

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4
Q

Sunitimib

A

MOA: VEGF and PDGF TK antagonist

TU: renal cell carcinoma

PK: CYP3A4 metabolism, high protein binding, PO

Tox: CHF, MI, teratogenic, hand-foot syndrome

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5
Q

Everolimus

A

MOA: mTOR inhibition (anti-VEGF, G1/S transition block)

PK: CYP3A4 metabolism

Resistance: MDR

Tox: lymphoma, renal arterial and venous thrombosis

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6
Q

Tamisorolimus

A

MOA: mTOR inhibition (anti-VEGF, G1/S transition block)

PK: CYP3A4 metabolism

Resistance: MDR

Tox: lymphoma, renal arterial and venous thrombosis

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7
Q

Lenalidomide, pamalidomide, thalidomide

A

MOA: suppress immune and inflammatory response, antiangiogenic, Th2 > Th1 activation

TU: MM

PK: PO, renal excretion

Tox: peripheral neuropathy, DVT (warfarin indicated in MM), severe teratogenic effects (phocomelia)

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