Chronic Lymphocytic Anemia Cases--Nikcevich Flashcards
CD5+, CD19+, CD20+, CD23+
flow cytometry
CLL
CD5+, CD23-, cyclin D1 +
flow cytometry
mantle cell lymphoma
CD38 +
vs
CD38 -
prognosis
CD38 -
–> better prognosis
13q-
mutation in CLL
creates fragile cytoskeletons
“smudge cells” seen on slides
indicates good prognosis
Mutated Ig VH indicates…
more mature B-cells
better prognosis
17p-
Richter’s transformation
–> poor prognostic sign
–> causes BM failure
–> can occur anytime in course of CLL
How does autoimmune hemolytic anemia sequele of CLL correspond to CLL recurrence?
it doesn’t
AHA may occur anytime after CLL, esp when it is remission
Ibrutinib
B-cell tyrosine kinase receptor antagonist
used to treat pure red cell aplasia 2˚ to CLL
Pure red cell aplasia 2˚ to ALL Tx
ibrutinib
Why can you get a hoarse voice from leukemias/lymphomas?
lymphadenopathy of thoracic nodes can impinge the recurrent laryngeal nerve