Chronic Lymphocytic Anemia Cases--Nikcevich Flashcards

1
Q

CD5+, CD19+, CD20+, CD23+

flow cytometry

A

CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CD5+, CD23-, cyclin D1 +

flow cytometry

A

mantle cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CD38 +

vs

CD38 -

prognosis

A

CD38 -

–> better prognosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

13q-

mutation in CLL

A

creates fragile cytoskeletons

“smudge cells” seen on slides

indicates good prognosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Mutated Ig VH indicates…

A

more mature B-cells

better prognosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

17p-

A

Richter’s transformation

–> poor prognostic sign

–> causes BM failure

–> can occur anytime in course of CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does autoimmune hemolytic anemia sequele of CLL correspond to CLL recurrence?

A

it doesn’t

AHA may occur anytime after CLL, esp when it is remission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Ibrutinib

A

B-cell tyrosine kinase receptor antagonist

used to treat pure red cell aplasia 2˚ to CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pure red cell aplasia 2˚ to ALL Tx

A

ibrutinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why can you get a hoarse voice from leukemias/lymphomas?

A

lymphadenopathy of thoracic nodes can impinge the recurrent laryngeal nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly