Clinical Toxicology

Question 1

Toxicology

Answer 1

The study of the adverse effects of chemicals on living organisms

Question 2

Dose-response Relationship

Answer 2

Within a population, the proportion of individuals responding to a given dose

Question 3

Anticholinesterase Syndrome

Answer 3

Organophosphate and carbamate insecticides:
-> sweating, miosis, lacrimation, sialorrhea, wheezing, abdominal cramps, vomiting, diarrhea, bradycardia, hypotension, blurred vision, incontinence

Question 4

Hemoglobinopathy Syndromes

Answer 4

CO poisoning

-> Hypoxia, headache, disorientation, coma, nausea, vomiting, cardiac dysfunction, acidosis and death

Question 5

Narcotic Overdose

Answer 5

Pinpoint pupils, respiratory depression and hypotension; rarely, CNS excitation and pupillary dilatation

Question 6

Sympathomimetic Excess

Answer 6

Nervousness, agitation, tremor, diaphoresis/dehydration with time, CNS excitation, hypertension, tachycardia, and seizures

Question 7

Withdrawal Syndrome

Answer 7

Opiate withdrawal - mydriasis, piloerection, rhinorrhea and lacrimation; not associated with seizures

Question 8

What are common signs of poisoning?

Answer 8

• Cardiac Conduction
• Metabolic Acidosis
• GI Dysfunction
• Seizures